제품 > 항체 > 다중클론항체(pAb)

BDNF Rabbit pAb (A1307)

Tested applications:WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP InhibitionReactivity:Human, Mouse, Rat

Western blot analysis of various lysates using BDNF Rabbit pAb (A1307) at 1:1000 dilution incubated overnight at 4℃.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25 μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 10s.

Review

Overview

Product name	BDNF Rabbit pAb
Catalog No.	A1307
Host species	Rabbit
Purification method	Affinity purification
Isotype	IgG

Background

This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders.

Immunogen information

Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 20-247 of human BDNF (NP_733928.1).
Sequence	PMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR
Gene ID
Swiss Prot
Synonyms	ANON2; BULN2; BDNF
Calculated MW	28kDa
Observed MW	40kDa

Applications

Reactivity	Human, Mouse, Rat
Tested applications	WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP Inhibition
Recommended dilution	WB 1:500 - 1:1000 ELISA Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Storage buffer	Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH7.3.
Key application	Western blotting
Positive samples	SH-SY5Y, U-87 MG
Cellular location	Secreted.
Customer validation	(Rat brain) WB(Rattus norvegicus, Mus musculus, Homo sapiens) IF(Rattus norvegicus) ELISA(Rattus norvegicus)

Documents

Certificate of Compliance

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Lot number

Research Area

BDNF Rabbit pAb images

Western blot - BDNF Rabbit pAb (A1307)

* For research use only. Not for therapeutic or diagnostic purposes.

Submit an review for A1307

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Reviews List

Product Protocols

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

International Journal of Biological Sciences

Application:

IF:

6.58

Species:

Rattus norvegicus

PMID:

27489501

Title:

BDNF-mediates Down-regulation of MicroRNA-195 Inhibits Ischemic Cardiac Apoptosis in Rats

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Journal of Cellular And Molecular Medicine

Application:

IF:

5.31

Species:

Rattus norvegicus

PMID:

28098423

Title:

Brain-derived neurotrophic factor attenuates doxorubicin-induced cardiac dysfunction through activating Akt signalling in rats

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

The American journal of pathology

Application:

IF:

4.307

Species:

Rattus norvegicus

PMID:

30121256

Title:

DNA Methylation and the YAP/WWTR1 Pathway Prevent Pathological Remodeling during Bladder Obstruction by Limiting Expression of BDNF

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Journal of affective disorders

Application:

IF:

4.839

Species:

Mus musculus

PMID:

30172225

Title:

Inhibition of activated astrocyte ameliorates lipopolysaccharide-induced depressive-like behaviors

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Behavioural brain research

Application:

IF:

3.332

Species:

Rattus norvegicus

PMID:

30703397

Title:

Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats.

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Pharmacology, Biochemistry, and Behavior

Application:

IF:

3.533

Species:

Mus musculus

PMID:

31866390

Title:

Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role of BDNF-TrkB signaling

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Evidence-based Complementary and Alternative Medicine

Application:

IF:

2.629

Species:

Rattus norvegicus

PMID:

28761498

Title:

Tranquilizing and Allaying Excitement Needling Method Affects BDNF and SYP Expression in Hippocampus.

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Brain Res Bull

Application:

IF:

4.077

Species:

Mus musculus

PMID:

32871241

Title:

Myocardial infarction-induced anxiety-like behavior is associated with epigenetic alterations in the hippocampus of rat

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Front Pharmacol

Application:

IF:

5.81

Species:

Rattus norvegicus

PMID:

34093193

Title:

Jiedu Tongluo Granules Ameliorates Post-stroke Depression Rat Model via Regulating NMDAR/BDNF Signaling Pathway

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Front Bioeng Biotechnol

Application:

IF:

5.89

Species:

Rattus norvegicus

PMID:

32719783

Title:

Conductive Hydroxyethyl Cellulose/Soy Protein Isolate/Polyaniline Conduits for Enhancing Peripheral Nerve Regeneration via Electrical Stimulation

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Translational psychiatry

Application:

IF:

7.98

Species:

Mus musculus

PMID:

36171191

Title:

A key role of miR-132-5p in the prefrontal cortex for persistent prophylactic actions of (R)-ketamine in mice - PMC

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

International journal of nanomedicine

Application:

IF:

7.03

Species:

Mus musculus

PMID:

36246933

Title:

Selenium Nanoparticles-Enriched Lactobacillus casei ATCC 393 Prevents Cognitive Dysfunction in Mice Through Modulating Microbiota-Gut-Brain Axis - PMC

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Neurotox Res

Application:

IF:

Species:

Rattus norvegicus

PMID:

36435923

Title:

Biogenic Selenium Nanoparticles Attenuate Aβ25–35-Induced Toxicity in PC12 Cells via Akt/CREB/BDNF Signaling Pathway

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Metabolic brain disease

Application:

IF:

3.65

Species:

Mus musculus

PMID:

36543978

Title:

D-beta-hydroxybutyrate protects against microglial activation in lipopolysaccharide-treated mice and BV-2 cells

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Free radical biology & medicine

Application:

IF:

8.1

Species:

Mus musculus

PMID:

36493983

Title:

TrkB agonist N-acetyl serotonin promotes functional recovery after traumatic brain injury by suppressing ferroptosis via the PI3K/Akt/Nrf2/Ferritin H pathway

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Heliyon

Application:

IF:

3.77

Species:

Mus musculus

PMID:

36578409

Title:

Wuzi Yanzong Pill relieves CPZ-induced demyelination by improving the microenvironment in the brain - PMC

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Nature communications

Application:

IF:

17.69

Species:

Mus musculus

PMID:

36797299

Title:

Nicotine rebalances NAD+ homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity - PMC

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

International journal of molecular sciences

Application:

IF:

6.2

Species:

Rattus norvegicus

PMID:

36901891

Title:

Effects of Maternal High-Fructose Diet on Long Non-Coding RNAs and Anxiety-like Behaviors in Offspring - PMC

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

International journal of pharmaceutics

Application:

IF:

6.51

Species:

Homo sapiens

PMID:

37527732

Title:

Borneol-modified PEGylated graphene oxide as a nanocarrier for brain-targeted delivery of ginsenoside Rg1 against depression

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Brain research

Application:

IF:

3.61

Species:

Mus musculus

PMID:

27328426

Title:

Hyperforin promotes post-stroke functional recovery through interleukin (IL) 17A-mediated angiogenesis

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

Molecular neurobiology

Application:

WB, ELISA

IF:

5.68

Species:

Rattus norvegicus

PMID:

36735179

Title:

Mechanism of Molecular Activity of Yolkin—a Polypeptide Complex Derived from Hen Egg Yolk—in PC12 Cells and Immortalized Hippocampal Precursor Cells H19-7 - PMC

References for BDNF Rabbit pAb (A1307)

Product:

BDNF Rabbit pAb

Journal:

International immunopharmacology

Application:

IF:

5.71

Species:

Mus musculus

PMID:

37001383