Basic Information
| Clone | Zolbetuximab Biosimilar |
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| Molecular Weight | 150 kDa |
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| Endotoxin | <1EU/mg (<0.001EU/μg)Determined by LAL gel clotting assay |
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| Sterility | 0.2 μm filtration |
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| Aggregation | <5% Determined by SECP |
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| Purity | >95% Determined by SDS-PAGE |
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Product Information
| Production | Purified from cell culture supernatant in an animal-free facility |
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| Purification | Protein A or G purification |
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| Storage | 2 - 8°C for up to 4 weeks and -80°C for long term storage (Avoid repeated freezing and thawing) |
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Target Background
Zolbetuximab is a humanized monoclonal antibody directed against the human protein Claudin 18.2 (the isoform 2 of Claudin), and potentially used for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. Zolbetuximab is an Fc-engineered, humanized, monoclonal antibody (IgG1κ isotype). Zolbetuximab biosimilar uses the same protein sequences as the potential therapeutic antibody zolbetuximab .Claudin-18 in humans is a protein encoded by the CLDN18 gene. The CLDN18 protein belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. Isoform 2 (Claudin 18.2) is abundant in gastric tumors.
Immunogen Information
| Isotype | Human IgG1 kappa |
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| Immunogen | Human Claudin 18 |
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| RecommendedIsotype Control(s) | In Vivo Grade Recombinant Human IgG1 Kappa Isotype Control Antibody |
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| Recommended Dilution Buffer | 1×PBS pH 7.0 |
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* For research use only. Not for therapeutic or diagnostic purposes.
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