Basic Information
| Clone | Tanezumab Biosimilar |
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| Molecular Weight | 150 kDa |
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| Endotoxin | <1EU/mg (<0.001EU/μg)Determined by LAL gel clotting assay |
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| Sterility | 0.2 μm filtration |
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| Aggregation | <5% Determined by SECP |
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| Purity | >95% Determined by SDS-PAGE |
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Product Information
| Production | Purified from cell culture supernatant in an animal-free facility |
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| Purification | Protein A or G purification |
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| Storage | 2 - 8°C for up to 4 weeks and -80°C for long term storage (Avoid repeated freezing and thawing) |
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Target Background
What is tanezumab biosimilar research grade? Tanezumab is a humanized IgG2-kappa monoclonal antibody against nerve growth factor (NGF) as a treatment for pain via a novel mechanisms different from conventional pain-killer drugs. NGF levels increase in the body as a result of injury, inflammation or in chronic pain states. Tanezumab selectively targets, binds to, and inhibits NGF. Tanezumab acts in the periphery in a different manner than opioids and other analgesics, including nonsteroidal anti-inflammatory drugs (NSAIDs), and in studies to date, tanezumab has not demonstrated a risk of addiction, misuse or dependence. Tanezumab biosimilar uses the same protein sequences as the therapeutic antibody tanezumab.
Immunogen Information
| Isotype | Human IgG2 kappa |
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| Immunogen | Human NGF |
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| RecommendedIsotype Control(s) | In Vivo Grade Recombinant Human IgG2 Kappa Isotype Control Antibody |
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| Recommended Dilution Buffer | 1×PBS pH 7.0 |
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* For research use only. Not for therapeutic or diagnostic purposes.
