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Human Trop-2 Monoclonal Antibody (YR0018)

Datasheet

ABclonal: - Human Trop-2 Monoclonal Antibody (YR0018)

Direct ELISA binding curve demonstrating the recognition of Human Anti-Human Trop-2 (Research Grade Sacituzumab Biosimilar) Monoclonal Antibody to Trop-2. The target protein was coated onto the microplate well surface, followed by binding of the antibody. A donkey anti-human IgG HRP conjugate was used for detection.

ABclonal: - Human Trop-2 Monoclonal Antibody (YR0018)

Human Trop-2 SPR assay. Determined through SPR assay, the Human Anti-Human Trop-2 (Research Grade Sacituzumab Biosimilar) Monoclonal Antibody is Capable of binding to Human Trop-2 with an affinity constant of 18.8 nM.

Basic Information

CloneSacituzumab Biosimilar
Molecular Weight150 kDa
Endotoxin<1EU/mg (<0.001EU/μg)Determined by LAL gel clotting assay
Sterility0.2 μm filtration
Aggregation<5% Determined by SECP
Purity>95% Determined by SEC-HPLC
ProductionPurified from cell culture supernatant in an animal-free facility
PurificationProtein A or G purification
Storage2 - 8°C for up to 4 weeks and -80°C for long term storage (Avoid repeated freezing and thawing)
Sacituzumab govitecan is a Trop-2-directed antibody and topoisomerase inhibitor drug conjugate used for the treatment of metastatic triple-negative breast cancer and metastatic urothelial cancer. Triple-negative breast cancer is a type of breast cancer that tests negative for estrogen receptors, progesterone receptors and human epidermal growth factor receptor 2 (HER2) protein. Therefore, triple-negative breast cancer does not respond to hormonal therapy medicines or medicines that target HER2.Sacituzumab govitecan is a conjugate of the humanized anti-Trop-2 monoclonal antibody linked with SN-38, the active metabolite of irinotecan. Each antibody having on average 7.6 molecules of SN-38 attached. SN-38 is too toxic to administer directly to patients, but linkage to an antibody allows the drug to specifically target cells containing Trop-2.
IsotypeHuman IgG1 kappa
ImmunogenHuman Trop-2
RecommendedIsotype Control(s)In Vivo Grade Recombinant Human IgG1 Kappa Isotype Control Antibody
Recommended Dilution Buffer1×PBS pH 7.0
ABclonal: - Human Trop-2 Monoclonal Antibody (YR0018)}

- Human Trop-2 Monoclonal Antibody (YR0018)

Direct ELISA binding curve demonstrating the recognition of Human Anti-Human Trop-2 (Research Grade Sacituzumab Biosimilar) Monoclonal Antibody to Trop-2. The target protein was coated onto the microplate well surface, followed by binding of the antibody. A donkey anti-human IgG HRP conjugate was used for detection.
ABclonal: - Human Trop-2 Monoclonal Antibody (YR0018)}

- Human Trop-2 Monoclonal Antibody (YR0018)

Human Trop-2 SPR assay. Determined through SPR assay, the Human Anti-Human Trop-2 (Research Grade Sacituzumab Biosimilar) Monoclonal Antibody is Capable of binding to Human Trop-2 with an affinity constant of 18.8 nM.

* For research use only. Not for therapeutic or diagnostic purposes.