Basic Information
| Clone | 10F.9G2.1 |
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| Molecular Weight | 150 kDa |
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| Endotoxin | <1EU/mg (<0.001EU/μg)Determined by LAL gel clotting assay |
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| Sterility | 0.2 μm filtration |
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| Aggregation | <5% Determined by SECP |
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| Purity | >95% Determined by SDS-PAGE |
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Product Information
| Production | Purified from cell culture supernatant in an animal-free facility |
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| Purification | Protein A or G purification |
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| Storage | 2 - 8°C for up to 4 weeks and -80°C for long term storage (Avoid repeated freezing and thawing) |
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Target Background
The rat anti-mouse PD-L1 monoclonal antibody 10F.9G2 (rat IgG2b kappa) reacts with the mouse PD-L1 protein (programmed death ligand-1, B7-H1 or CD274), a member of the B7 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD-1 and anti-mouse PD-L1 antibodies which block the interaction between the PD-L1 protein and its receptor PD-1 protein. The 10F.9G2 monoclonal antibody blocks the binding of the mouse PD-L1 protein to the mouse PD-1 protein.
Immunogen Information
| Isotype | mouse IgG2b, kappa. |
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| Immunogen | mouse PD-L1 cDNA and mouse PD-L1 CHO transfectants |
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| RecommendedIsotype Control(s) | In Vivo Grade Recombinant Mouse IgG2b Kappa Isotype Control Antibody |
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| Recommended Dilution Buffer | 1×PBS pH 7.0 |
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* For research use only. Not for therapeutic or diagnostic purposes.
