제품 > 항체 > 단일클론항체(mAb)

[KD Validated] GPX4 Rabbit mAb (A11243)

Tested applications:WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP InhibitionReactivity:Human, Mouse, Rat

Western blot analysis of various lysates using [KD Validated] GPX4 Rabbit mAb (A11243) at 1:1000 dilution incubated overnight at 4℃.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25 μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 15s.

Western blot analysis of lysates from wild type (WT) and GPX4 knockdown (KD) U-87 MG cells using [KD Validated] GPX4 Rabbit mAb (A11243) at 1:1000 dilution incubated overnight at 4℃.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25 μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 60s.

ABclonal:Immunofluorescence - [KD Validated] GPX4 Rabbit mAb (A11243)

Confocal imaging of paraffin-embedded Mouse testis tissue using [KD Validated] GPX4 Rabbit mAb (A11243, dilution 1:200) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007, dilution 1:500) (Red). DAPI was used for nuclear staining (Blue). High pressure antigen retrieval performed with 0.01M Citrate Buffer (pH 6.0) prior to IF staining. Objective: 40x.

Review

Overview

Product name	[KD Validated] GPX4 Rabbit mAb
Catalog No.	A11243
Host species	Rabbit
Purification method	Affinity purification
Isotype	IgG
CloneNo.	ARC0558

Background

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization.

Immunogen information

Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GPX4 (P36969).
Sequence	MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAF
Gene ID
Swiss Prot
Synonyms	MCSP; SMDS; GPx-4; PHGPx; snGPx; GSHPx-4; snPHGPx; [KD Validated] GPX4
Calculated MW	22kDa
Observed MW	20kDa

Applications

Reactivity	Human, Mouse, Rat
Tested applications	WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP Inhibition
Recommended dilution	WB 1:1000 - 1:6000 IF/ICC 1:200 - 1:800 ELISA Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Storage buffer	Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% sodium azid, 0.05% BSA, 50% glycerol, pH7.3.
Key application	Western blotting Immunofluorescence
Positive samples	U-87 MG, PC-3, Jurkat, Mouse testis, Rat testis
Cellular location	Cytoplasm, Mitochondrion.
Customer validation	(PC-3、HL-60、HepG2、HeLa、U2-OS、293T) WB(Rattus norvegicus, Mus musculus, Homo sapiens, Mus musculus, Other, Gallus gallus, Rattus norvegicus, Cyprinus carpio) Co-IP(Homo sapiens) IHC(Homo sapiens, Mus musculus) IF(Homo sapiens, Mus musculus) IF(Mus musculus, Ctenopharyngodon idellus) IHC(Mus musculus) WB(Mus musculus, Ctenopharyngodon idellus)

Documents

Certificate of Compliance

To download a Certificate of Compliance, please enter your Lot number below:

Lot number

Research Area

[KD Validated] GPX4 Rabbit mAb images

Western blot - [KD Validated] GPX4 Rabbit mAb (A11243)

Immunofluorescence - [KD Validated] GPX4 Rabbit mAb (A11243)

* For research use only. Not for therapeutic or diagnostic purposes.

Submit an review for A11243

Please submit reviews to your technical sales specialist directly. Alternatively, email us at info@abclonal.co.kr

Reviews List

Product Protocols

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Free Radic Biol Med

Application:

IF:

7.376

Species:

Rattus norvegicus

PMID:

34246777

Title:

Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Eur J Pharmacol

Application:

IF:

4.432

Species:

Rattus norvegicus

PMID:

34280397

Title:

Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4 0

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Oxid Med Cell Longev

Application:

IF:

6.54

Species:

Mus musculus

PMID:

34925691

Title:

Dihydroartemisinin Induces Ferroptosis in HCC by Promoting the Formation of PEBP1/15-LO

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

J Inflamm Res

Application:

IF:

6.922

Species:

Rattus norvegicus

PMID:

34703276

Title:

Ferroptosis is Involved in Hyperoxic Lung Injury in Neonatal Rats

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Oxidative medicine and cellular longevity

Application:

IF:

6.54

Species:

Mus musculus

PMID:

35186185

Title:

Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mice via Inhibiting 15-Lipoxygenase-1-Mediated Microglia and Endothelial Cell Ferroptosis

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Neuroscience

Application:

IF:

3.7

Species:

Rattus norvegicus

PMID:

36180007

Title:

MicroRNA‑27a Aggravates Ferroptosis during early Ischemic Stroke of Rats Through Nrf2

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

ACS biomaterials science & engineering

Application:

IF:

5.39

Species:

Homo sapiens

PMID:

36070516

Title:

A Self-Assembly ICG Nanoparticle Potentiating Targeted Photothermal and Photodynamic Therapy in NSCLC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

International immunopharmacology

Application:

IF:

5.71

Species:

Mus musculus

PMID:

36067654

Title:

Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Toxicology letters

Application:

IF:

4.27

Species:

Mus musculus

PMID:

35963425

Title:

Acrylamide induces ferroptosis in HSC-T6 cells by causing antioxidant imbalance of the XCT-GSH-GPX4 signaling and mitochondrial dysfunction

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Metallomics : integrated biometal science

Application:

IF:

4.63

Species:

Mus musculus

PMID:

36002020

Title:

Transcriptomic analysis reveals the effects of maternal selenium deficiency on placental transport, hormone synthesis, and immune response in mice

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Oxidative medicine and cellular longevity

Application:

IF:

7.31

Species:

Mus musculus

PMID:

36238648

Title:

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Frontiers in cardiovascular medicine

Application:

IF:

5.84

Species:

Mus musculus

PMID:

36172581

Title:

Exosomes derived from pericardial adipose tissues attenuate cardiac remodeling following myocardial infarction by Adipsin-regulated iron homeostasis - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Materials today. Bio

Application:

IF:

10.76

Species:

Mus musculus

PMID:

36176720

Title:

Ignored role of polyphenol in boosting reactive oxygen species generation for polyphenol/chemodynamic combination therapy - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Journal of ethnopharmacology

Application:

IF:

5.19

Species:

Rattus norvegicus

PMID:

36539070

Title:

Integration of metabolomics and transcriptomics to reveal ferroptosis is involved in Tripterygium wilfordii polyglycoside tablet-induced testicular injury

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Bioorganic & medicinal chemistry

Application:

IF:

3.46

Species:

Rattus norvegicus

PMID:

36580744

Title:

4Dual functional antioxidant and butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of novel melatonin …

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Frontiers in pharmacology

Application:

IF:

5.98

Species:

Homo sapiens

PMID:

36506541

Title:

Fuzheng Nizeng Decoction regulated ferroptosis and endoplasmic reticulum stress in the treatment of gastric precancerous lesions: A mechanistic study based on metabolomics coupled with transcriptomics - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Research square

Application:

IF:

Species:

Homo sapiens

PMID:

36778475

Title:

Regulation of Ferroptosis by Transcription Factor E2F1 and RB - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

International journal of chronic obstructive pulmonary disease

Application:

IF:

2.89

Species:

Mus musculus

PMID:

36817367

Title:

Relationship Between ACSL4-Mediated Ferroptosis and Chronic Obstructive Pulmonary Disease - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Oxidative medicine and cellular longevity

Application:

IF:

7.31

Species:

Rattus norvegicus

PMID:

36820405

Title:

Ferroptosis in Rat Lung Tissue during Severe Acute Pancreatitis-Associated Acute Lung Injury: Protection of Qingyi Decoction - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Metallomics : integrated biometal science

Application:

IF:

4.63

Species:

Homo sapiens

PMID:

36869799

Title:

Roles of glutathione peroxidase 4 on the mercury-triggered ferroptosis in renal cells: Implications for the antagonism between selenium and mercury

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Molecular nutrition & food research

Application:

IF:

6.57

Species:

Mus musculus

PMID:

36989169

Title:

Farnesol exerts protective effects against chronic sleep deprivation‐induced cognitive impairment via activation SIRT1/Nrf2 pathway in the hippocampi of adult mice

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Molecular medicine (Cambridge, Mass.)

Application:

IF:

6.37

Species:

Homo sapiens

PMID:

36977984

Title:

The promotion action of AURKA on post-ischemic angiogenesis in diabetes-related limb ischemia - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Life sciences

Application:

Co-IP

IF:

6.78

Species:

Homo sapiens

PMID:

36958437

Title:

TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Acta pharmacologica Sinica

Application:

IF:

7.16

Species:

Homo sapiens

PMID:

37225847

Title:

Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Cell reports. Medicine

Application:

IF:

16.98

Species:

Mus musculus

PMID:

37075700

Title:

Self-adaptive nanoassembly enabling turn-on hypoxia illumination and periphery/center closed-loop tumor eradication - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Naunyn-Schmiedeberg's archives of pharmacology

Application:

IF:

3.19

Species:

Mus musculus

PMID:

37160483

Title:

Liquiritin reduces ferroptosis in doxorubicin-induced cardiotoxicity through targeting SLC7A11/GPX4 pathway

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Antioxidants (Basel, Switzerland)

Application:

IF:

7.67

Species:

Homo sapiens

PMID:

37507910

Title:

Hyperforin Enhances Heme Oxygenase-1 Expression Triggering Lipid Peroxidation in BRAF-Mutated Melanoma Cells and Hampers the Expression of Pro-Metastatic Markers - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Heliyon

Application:

IF:

3.77

Species:

Rattus norvegicus

PMID:

38053888

Title:

Taxifolin protects against doxorubicin-induced cardiotoxicity and ferroptosis by adjusting microRNA-200a-mediated Nrf2 signaling pathway - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Experimental & molecular medicine

Application:

IF:

12.15

Species:

Rattus norvegicus

PMID:

37907744

Title:

HMGB1 induces hepcidin upregulation in astrocytes and causes an acute iron surge and subsequent ferroptosis in the postischemic brain

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Application:

IF:

7.41

Species:

Mus musculus

PMID:

37429233

Title:

Protective benefits of salvianic acid A against retinal iron overload by inhibition of ferroptosis

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Aging

Application:

IF:

5.95

Species:

Rattus norvegicus

PMID:

37916995

Title:

Capsaicin alleviates doxorubicin-induced acute myocardial injury by regulating iron homeostasis and PI3K-Akt signaling pathway - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Neural regeneration research

Application:

IF:

6.05

Species:

Rattus norvegicus

PMID:

37056142

Title:

Reperfusion after hypoxia-ischemia exacerbates brain injury with compensatory activation of the anti-ferroptosis system: based on a novel rat model

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Nature communications

Application:

WB, IHC

IF:

17.69

Species:

Homo sapiens, Mus musculus

PMID:

36932056

Title:

A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Redox biology

Application:

WB, IF

IF:

10.78

Species:

Homo sapiens

PMID:

37267686

Title:

Energy stress modulation of AMPK/FoxO3 signaling inhibits mitochondria-associated ferroptosis - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Evidence-based complementary and alternative medicine : eCAM

Application:

WB, IF

IF:

2.65

Species:

Homo sapiens

PMID:

36133791

Title:

Exploring the Mechanism of Realgar against Esophageal Cancer Based on Ferroptosis Induced by ROS-ASK1-p38 MAPK Signaling Pathway - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Biochemical pharmacology

Application:

IF:

6.1

Species:

Homo sapiens

PMID:

36210578

Title:

Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Redox biology

Application:

IF:

10.78

Species:

Homo sapiens, Mus musculus

PMID:

37890360

Title:

HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI-CKD progression

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Theranostics

Application:

IF:

11.6

Species:

Homo sapiens

PMID:

37771765

Title:

Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE-/-mice - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Biochemical and biophysical research communications

Application:

IF:

3.32

Species:

Homo sapiens

PMID:

37995455

Title:

Gigantol exerts anti-lung cancer activity by inducing ferroptosis via SLC7A11-GPX4 axis

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Journal of translational medicine

Application:

IF:

8.44

Species:

Homo sapiens

PMID:

38169402

Title:

The SOX4/EZH2/SLC7A11 signaling axis mediates ferroptosis in calcium oxalate crystal deposition-induced kidney injury - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Toxicology and applied pharmacology

Application:

IF:

4.46

Species:

Mus musculus,Rattus norvegicus

PMID:

38142782

Title:

Resveratrol protects against doxorubicin-induced cardiotoxicity by attenuating ferroptosis through modulating the MAPK signaling pathway

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Cellular signalling

Application:

IF:

4.85

Species:

Mus musculus

PMID:

38086436

Title:

Rev-erb attenuates diabetic myocardial injury through regulation of ferroptosis

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Cellular signalling

Application:

IF:

4.85

Species:

Mus musculus,Rattus norvegicus

PMID:

37972803

Title:

PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Virologica Sinica

Application:

IF:

6.94

Species:

Homo sapiens,Other

PMID:

38104890

Title:

Ferroptosis contributes to JEV-induced neuronal damage and neuroinflammation

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Application:

IF:

17.52

Species:

Mus musculus

PMID:

38358041

Title:

Near Infrared Responsive Gold Nanorods Attenuate Osteoarthritis Progression by Targeting TRPV1

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Journal of agricultural and food chemistry

Application:

IF:

5.89

Species:

Rattus norvegicus

PMID:

38038704

Title:

Astaxanthin Protects against Alcoholic Liver Injury via Regulating Mitochondrial Redox Balance and Calcium Homeostasis

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Phytotherapy research : PTR

Application:

IF:

7.2

Species:

Mus musculus

PMID:

37500597

Title:

Curdione inhibits ferroptosis in isoprenalineinduced myocardial infarction via regulating Keap1/Trx1/GPX4 signaling pathway

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Toxicology

Application:

IF:

4.5

Species:

Gallus gallus

PMID:

38325558

Title:

miR-15b-5p promotes HgCl2-induced chicken embryo kidney cells ferroptosis by targeting -TrCP-mediated ATF4 ubiquitin degradation

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Biochemical pharmacology

Application:

IF:

5.8

Species:

Mus musculus

PMID:

38387530

Title:

IL-23p19 deficiency reduces M1 macrophage polarization and improves stress-induced cardiac remodeling by alleviating macrophage ferroptosis in mice

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Neoplasia

Application:

IF:

6.218

Species:

Mus musculus

PMID:

34768109

Title:

ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Biochemical pharmacology

Application:

WB, IF

IF:

6.1

Species:

Mus musculus

PMID:

36502872

Title:

Activated AMPK mitigates diabetes-related cognitive dysfunction by inhibiting hippocampal ferroptosis

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Redox biology

Application:

IF:

10.78

Species:

Mus musculus, Rattus norvegicus

PMID:

37531930

Title:

EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2 - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

PloS one

Application:

WB, IHC, IF

IF:

3.75

Species:

Homo sapiens

PMID:

36516169

Title:

Aspirin mediates protection from diabetic kidney disease by inducing ferroptosis inhibition - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Application:

IF:

17.52

Species:

Rattus norvegicus

PMID:

36808838

Title:

Suppressing Mesenchymal Stromal Cell Ferroptosis Via Targeting a MetabolismEpigenetics Axis Corrects their Poor Retention and Insufficient Healing Benefits in

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Nature communications

Application:

IF:

17.69

Species:

Homo sapiens

PMID:

37805657

Title:

URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Experimental cell research

Application:

WB, IHC

IF:

4.14

Species:

Homo sapiens

PMID:

37940066

Title:

Hypoxia promotes the growth and metastasis of ovarian cancer cells by suppressing ferroptosis via upregulating SLC2A12

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Journal of assisted reproduction and genetics

Application:

IF:

3.1

Species:

Homo sapiens

PMID:

38526774

Title:

Mechanisms of YAP1-mediated trophoblast ferroptosis in recurrent pregnancy loss

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Application:

IF:

7.5

Species:

Mus musculus

PMID:

38583338

Title:

Mastoparan M promotes functional recovery in stroke mice by activating autophagy and inhibiting ferroptosis

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Journal of agricultural and food chemistry

Application:

IF:

6.1

Species:

Homo sapiens

PMID:

38483540

Title:

Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Food & function

Application:

IF:

6.1

Species:

Rattus norvegicus

PMID:

37982854

Title:

Astaxanthin alleviates fine particulate matter (PM2. 5)-induced lung injury in rats by suppressing ferroptosis and apoptosis

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

European journal of medicinal chemistry

Application:

Co-IP

IF:

7.08

Species:

Homo sapiens

PMID:

37801824

Title:

Discovery and optimization of indirubin derivatives as novel ferroptosis inducers for the treatment of colon cancer

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Virologica Sinica

Application:

IF:

6.94

Species:

Homo sapiens

PMID:

37690733

Title:

Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Application:

IF:

7.5

Species:

Homo sapiens

PMID:

38703506

Title:

Angelica sinensis polysaccharide combined with cisplatin reverses cisplatin resistance of ovarian cancer by inducing ferroptosis via regulating GPX4

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Cancer biomarkers : section A of Disease markers

Application:

IF:

3.1

Species:

Homo sapiens

PMID:

38250761

Title:

GPX4 inhibits apoptosis of thyroid cancer cells through regulating the FKBP8/Bcl-2 axis - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Naunyn-Schmiedeberg's archives of pharmacology

Application:

IF:

3.6

Species:

Mus musculus

PMID:

38896272

Title:

Gastrodin prevents myocardial injury in sleep-deprived mice by suppressing ferroptosis through SIRT6

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Gene

Application:

IF:

3.5

Species:

Homo sapiens

PMID:

38788818

Title:

Unveiling the role of APOM gene in liver cancer: Investigating the impact of hsa-miRNA-4489/MUC1-mediated ferroptosis on the advancement of

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Application:

IF:

4.3

Species:

Homo sapiens

PMID:

38897284

Title:

MiR-1909-5p targeting GPX4 affects the progression of aortic dissection by modulating nicotine-induced ferroptosis

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Phytomedicine : international journal of phytotherapy and phytopharmacology

Application:

IF:

7.9

Species:

Mus musculus

PMID:

38833791

Title:

Targeting antioxidant factor Nrf2 by raffinose ameliorates lipid dysmetabolism-induced pyroptosis, inflammation and fibrosis in NAFLD

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Pharmaceuticals (Basel, Switzerland)

Application:

IF:

4.6

Species:

Homo sapiens

PMID:

39065721

Title:

Ginsenoside RK1 Induces Ferroptosis in Hepatocellular Carcinoma Cells through an FSP1-Dependent Pathway - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Application:

IF:

4.8

Species:

Homo sapiens

PMID:

38970404

Title:

SREBP1mediated lipogenesis confers resistance to ferroptosis and improves endothelial injury

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Biomacromolecules

Application:

IF:

6.2

Species:

Mus musculus

PMID:

38779908

Title:

Paclitaxel Overload Supramolecular Oxidative Stress Nanoamplifier with a CDK12 Inhibitor for Enhanced Cancer Therapy

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Journal of virology

Application:

IF:

5.4

Species:

Mus musculus

PMID:

38899934

Title:

A BSL-2 compliant mouse model of SARS-CoV-2 infection for efficient and convenient antiviral evaluation

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Journal of nanobiotechnology

Application:

IF:

10.2

Species:

Mus musculus

PMID:

38951822

Title:

Cardiac-derived extracellular vesicles improve mitochondrial function to protect the heart against ischemia/reperfusion injury by delivering ATP5a1 - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Redox report : communications in free radical research

Application:

IF:

3.8

Species:

Mus musculus

PMID:

39150892

Title:

Sarmentosin alleviates doxorubicin-induced cardiotoxicity and ferroptosis via the p62-Keap1-Nrf2 pathway - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Pesticide biochemistry and physiology

Application:

IF:

4.7

Species:

Cyprinus carpio

PMID:

39084778

Title:

Emamectin benzoate exposure induced carp kidney injury by triggering mitochondrial oxidative stress to accelerate ferroptosis and autophagy

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Environmental pollution (Barking, Essex : 1987)

Application:

IF:

8.9

Species:

Mus musculus

PMID:

38423272

Title:

Inhalation exposure to polystyrene nanoplastics induces chronic obstructive pulmonary disease-like lung injury in mice through multi-dimensional assessment

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Cancer biology & therapy

Application:

IHC, WB

IF:

3.6

Species:

Mus musculus

PMID:

39345091

Title:

FASN contributes to ADM resistance of diffuse large B-cell lymphoma by inhibiting ferroptosis via nf-B/STAT3/GPX4 axis - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Journal of reproductive immunology

Application:

IF:

3.4

Species:

Homo sapiens

PMID:

39054220

Title:

IGF2BP3 participates in the pathogenesis of recurrent spontaneous abortion by regulating ferroptosis

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

CNS neuroscience & therapeutics

Application:

IF:

5.5

Species:

Homo sapiens

PMID:

39328008

Title:

Vitamin D3 Attenuates Neuropathic Pain via Suppression of Mitochondria-Associated Ferroptosis by Inhibiting PKC/NOX4 Signaling Pathway - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Journal of cancer research and clinical oncology

Application:

IF:

3.6

Species:

Homo sapiens

PMID:

39311951

Title:

Curcumin promotes ferroptosis in hepatocellular carcinoma via upregulation of ACSL4 - PMC

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Pesticide biochemistry and physiology

Application:

IF:

4.7

Species:

Gallus gallus

PMID:

38685251

Title:

Resveratrol alleviates inorganic arsenic-induced ferroptosis in chicken brain via activation of the Nrf2 signaling pathway

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Fish & shellfish immunology

Application:

IF:

4.7

Species:

Other

PMID:

39349229

Title:

Selenomethionine Alleviates Aeromonas Hydrophila-Induced Oxidative Stress and Ferroptosis Via the Nrf2/Ho1/Gpx4 Pathway in Grass Carp

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Free radical biology & medicine

Application:

IF:

7.4

Species:

Mus musculus

PMID:

38447853

Title:

Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Biochemical pharmacology

Application:

IF:

5.3

Species:

Rattus norvegicus

PMID:

39134283

Title:

Trimetazidine Attenuates Ischemia/Reperfusion-Induced Myocardial Ferroptosis by Modulating the Sirt3/Nrf2-GSH System and Reducing Mitochondrial Oxidative

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Pesticide biochemistry and physiology

Application:

IF, WB

IF:

4.2

Species:

Ctenopharyngodon idellus

PMID:

38582593

Title:

Chlorantraniliprole induces mitophagy, ferroptosis, and cytokine homeostasis imbalance in grass carp (Ctenopharyngodon idella) hepatocytes via the mtROS

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Free radical biology & medicine

Application:

IF:

7.1

Species:

Homo sapiens

PMID:

38301975

Title:

Zinc deficiency drives ferroptosis resistance by lactate production in esophageal squamous cell carcinoma

References for [KD Validated] GPX4 Rabbit mAb (A11243)

Product:

[KD Validated] GPX4 Rabbit mAb

Journal:

Cell death & disease

Application:

IF:

35.7

Species:

Mus musculus

PMID:

39433736

Title:

Identification of KW-2449 as a dual inhibitor of ferroptosis and necroptosis reveals that autophagy is a targetable pathway for necroptosis inhibitors to prevent ferroptosis - PMC