제품 > 항체 > 다중클론항체(pAb)

Mannose Receptor/CD206 Rabbit pAb (A8301)

Tested applications:WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP InhibitionReactivity:Mouse, Rat

Western blot analysis of various lysates using Mannose Receptor/CD206 Rabbit pAb (A8301) at 1:2000 dilution.
Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(AS014) at 1:10000 dilution.
Lysates/proteins: 25 μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection:ECL Basic Kit (RM00020).
Negative control (NC): Jurkat.
Exposuretime: 30s.

Overview

Product name	Mannose Receptor/CD206 Rabbit pAb
Catalog No.	A8301
Host species	Rabbit
Purification method	Affinity purification
Isotype	IgG

Background

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.

Immunogen information

Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 610-860 of human Mannose Receptor/CD206 (NP_002429.1).
Sequence	GLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCFKLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQKGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQSESEKKFLWKYVNRNDAQSAY
Gene ID
Swiss Prot
Synonyms	MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1; Mannose Receptor/CD206
Calculated MW	166kDa
Observed MW	190-250kDa

Applications

Reactivity	Mouse, Rat
Tested applications	WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP Inhibition
Recommended dilution	WB 1:1000 - 1:5000
Storage buffer	Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Key application	Western blotting
Positive samples	Rat lung
Cellular location	Cell membrane, Endosome membrane, Single-pass type I membrane protein
Customer validation	IF(Homo sapiens, Mus musculus, Sus domesticus, Rattus norvegicus) WB(Mus musculus, Homo sapiens, Rattus norvegicus, Mus musculus) FC(Homo sapiens) WB(Homo sapiens) IHC(Mus musculus, Rattus norvegicus, Homo sapiens) IF(Mus musculus)

Documents

Certificate of Compliance

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Lot number

Research Area

연구면역학 & 염증CDs

Mannose Receptor/CD206 Rabbit pAb images

Western blot - Mannose Receptor/CD206 Rabbit pAb (A8301)

* For research use only. Not for therapeutic or diagnostic purposes.

Product Protocols

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Scientific reports

Application:

IF:

3.8

Species:

Homo sapiens

PMID:

29109519

Title:

Network-pharmacology-based validation of TAMS/CXCL-1 as key mediator of XIAOPI formula preventing breast cancer development and metastasis

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Stem Cells and Development

Application:

IF:

3.272

Species:

Mus musculus

PMID:

31918626

Title:

RNA-Seq Reveals Underlying Transcriptomic Mechanisms of Bone Marrow-Derived Mesenchymal Stem Cells in the Regulation of Microglia-Mediated Neuroinflammation After Subarachnoid Hemorrhage

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Brain Research Bulletin

Application:

IF:

3.5

Species:

Mus musculus

PMID:

32272155

Title:

Morin exerts protective effects on encephalopathy and sepsis-associated cognitive functions in a murine sepsis model

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Int Endod J

Application:

FC, WB

IF:

Species:

Homo sapiens

PMID:

33075145

Title:

Ror β expression in Activated macrophages and Dental pulp stem cells

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Cell Death Dis

Application:

IF:

8.1

Species:

Homo sapiens

PMID:

33431821

Title:

The HIV protease inhibitor Saquinavir attenuates sepsis-induced acute lung injury and promotes M2 macrophage polarization via targeting matrix metalloproteinase-9

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Journal of Crohn's & colitis

Application:

IF:

8.3

Species:

Mus musculus

PMID:

35134154

Title:

Tollip orchestrates macrophage polarization to alleviate intestinal mucosal inflammation

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

International immunopharmacology

Application:

IF:

4.8

Species:

Mus musculus

PMID:

36095948

Title:

Msr1 Characterized by Chromatin Accessibility Mediates M2 Macrophages Polarization to Promote Gastric Cancer Progression

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Cell death & disease

Application:

IHC

IF:

8.1

Species:

Mus musculus

PMID:

35853880

Title:

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression - PMC

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Application:

IF:

6.9

Species:

Rattus norvegicus

PMID:

35486975

Title:

Dexmedetomidine attenuates perioperative neurocognitive disorders by suppressing hippocampal neuroinflammation and HMGB1/RAGE/NF-κB signaling pathway

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

ACS applied materials & interfaces

Application:

IF:

8.3

Species:

Mus musculus

PMID:

36327132

Title:

Leveraging Nanodrug Delivery System for Simultaneously Targeting Tumor Cells and M2 Tumor-Associated Macrophages for Efficient Colon Cancer Therapy

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Microbiology spectrum

Application:

IF:

3.7

Species:

Mus musculus

PMID:

36287014

Title:

Streptococcus suis Serotype 2 Infection Induces Splenomegaly with Splenocyte Apoptosis

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Microorganisms

Application:

IF:

4.5

Species:

Sus domesticus

PMID:

36677452

Title:

Interaction between Porcine Alveolar Macrophage-Tang Cells and Streptococcus suis Strains of Different Virulence: Phagocytosis and Apoptosis - PMC

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Cancers

Application:

IF:

5.2

Species:

Rattus norvegicus

PMID:

36358605

Title:

STING Contributes to Cancer-Induced Bone Pain by Promoting M1 Polarization of Microglia in the Medial Prefrontal Cortex - PMC

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Cells

Application:

IHC

IF:

7.7

Species:

Rattus norvegicus

PMID:

37048067

Title:

Modeling the Effects of Cypermethrin Toxicity on Ovalbumin-Induced Allergic Pneumonitis Rats: Macrophage Phenotype Differentiation and p38/STAT6 Signaling Are Candidate Targets of Pirfenidone Treatment - PMC

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Food Chem Toxicol

Application:

IF:

3.9

Species:

Mus musculus

PMID:

34111491

Title:

The Key Role of Autophagy in Silver Nanoparticle-Induced BV2 Cells Inflammation and Polarization

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Cancer cell international

Application:

IHC

IF:

6.4

Species:

Mus musculus

PMID:

37779195

Title:

HK3 stimulates immune cell infiltration to promote glioma deterioration - PMC

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Redox biology

Application:

IF:

10.7

Species:

Mus musculus

PMID:

37979447

Title:

CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-B pathway - PMC

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Application:

IHC

IF:

6.9

Species:

Homo sapiens

PMID:

37499456

Title:

Membrane vesicles from Lactobacillus johnsonii delay osteoarthritis progression via modulating macrophage glutamine synthetase/mTORC1 axis

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

European journal of pharmacology

Application:

IF:

4.2

Species:

Homo sapiens, Mus musculus

PMID:

37673366

Title:

Edaravone dexborneol ameliorates cognitive impairment by regulating the NF-B pathway through AHR and promoting microglial polarization towards the M2

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Brain research bulletin

Application:

IF:

3.5

Species:

Mus musculus

PMID:

38145759

Title:

Betaine eliminates CFA-induced depressive-like behaviour in mice may be through inhibition of microglia and astrocyte activation and polarization

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Biomedicines

Application:

IF:

4.7

Species:

Homo sapiens

PMID:

38398043

Title:

Multifunctional Exosomes Derived from M2 Macrophages with Enhanced Odontogenesis, Neurogenesis and Angiogenesis for Regenerative Endodontic Therapy: An In Vitro and In Vivo Investigation - PMC

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

International immunopharmacology

Application:

IF:

4.8

Species:

Mus musculus

PMID:

38350357

Title:

Human Amniotic MSCs-Mediated Anti-Inflammation of CD206hiIL-10hi Macrophages Alleviates Isoproterenol-Induced Ventricular Remodeling in Mice

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

J Transl Med

Application:

IF:

8.4

Species:

Mus musculus

PMID:

33568202

Title:

Rosuvastatin exerts anti-atherosclerotic effects by improving macrophage-related foam cell formation and polarization conversion via mediating autophagic activities.

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Asian journal of pharmaceutical sciences

Application:

WB, IF

IF:

10.7

Species:

Mus musculus

PMID:

36101893

Title:

Non-cytotoxic Nanoparticles Re-educating Macrophages Achieving both Innate and Adaptive Immune Responses for Tumor Therapy

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Molecules (Basel, Switzerland)

Application:

IF:

4.6

Species:

Mus musculus

PMID:

37513222

Title:

A Novel Bromophenol Compound from Leathesia nana Inhibits Breast Cancer in a Direct Tumor Killing and Immunotherapy Manner - PMC

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Cancer gene therapy

Application:

IF:

4.8

Species:

Mus musculus

PMID:

38555398

Title:

SDCBP modulates tumor microenvironment, tumor progression and anti-PD1 efficacy in colorectal cancer

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Application:

IHC

IF:

15.1

Species:

Mus musculus

PMID:

37635177

Title:

InflammationResponsive Hydrogel Spray for Synergistic Prevention of Traumatic Heterotopic Ossification via DualHomeostatic Modulation Strategy

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Journal of translational medicine

Application:

IF:

8.4

Species:

Rattus norvegicus

PMID:

39143617

Title:

Sciatic nerve stimulation alleviates neuropathic pain and associated neuroinflammation in the dorsal root ganglia in a rodent model - PMC

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Molecular brain

Application:

IF:

4.4

Species:

Mus musculus

PMID:

39223647

Title:

Electroacupuncture reduces inflammatory damage following cerebral ischemia-reperfusion by enhancing ABCA1-mediated efferocytosis in M2 microglia - PMC

References for Mannose Receptor/CD206 Rabbit pAb (A8301)

Product:

Mannose Receptor/CD206 Rabbit pAb

Journal:

Microorganisms

Application:

IF:

4.5

Species:

Mus musculus

PMID:

39338553