| Product name | Rabbit anti-Human IL-1β(CAP) |
|---|---|
| Catalog No. | RM17743 |
| Catagory | Elisa Antibody Kit |
| Application | CLIA |
| Description | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. |
| Immunogen | Recombinant Human IL-1β Protein |
| Purirty | Affinity purification |
| Ig Type | Rabbit IgG |
| Formulation | Supplied as a 0.2umfiltered solution in PBS with0.1%Braveds MB-1 , Ph7.4. |
| CrossReactivity | No cross-reactivity in ELISA assay with recombinant hIL-1A , hIL-1RA, hIL-18, hIL-33, mIL-1B, mIL-33, rIL-1A , rIL-1B |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. Preservative：0.05%ProClin 300. Avoid repeated freeze-thaw cycles. |
Human IL-1β Sanwich CLIA Immunoassay
| Recommended Concentration | Sample | |
|---|---|---|
| CLIA Capture | 1-4ug/mL | Rabbit anti-Human IL-1β(CAP)(Cat. No.RM17743) |
| CLIA Detection | 0.5-2ug/mL | Rabbit anti-Human IL-1β(DET)(Cat. No.RM17734) |
| Standard | 0.625-10ng/mL | Recombinant Human IL-1β Protein |
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