| Product name | Rabbit anti-Human cTnI mAb (CAP) |
|---|---|
| Catalog No. | RM17653 |
| Catagory | Elisa Antibody Kit |
| Application | multiplex assay |
| Description | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. |
| Immunogen | Nature Human cTnI Protein |
| Purirty | Affinity purification |
| Ig Type | Rabbit IgG |
| Formulation | Supplied as a 0.2um filtered solution in PBS with 0.1%Braveds MB-1, PH 7.4. |
| CrossReactivity | No cross-reactivity in multiplex assay with analogues. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. Preservative：0.05%ProClin 300. Avoid repeated freeze-thaw cycles. |
Human cTnI multiplex assay
| Recommended Concentration | Sample | |
|---|---|---|
| Capture | 6ug/106 | Rabbit anti-Human cTnI mAb (CAP)(Cat. No. RM17653) |
| Detection | 0.25-1ug/ml | Rabbit anti-Human cTnI mAb (DET)(Cat. No. RM17654) |
| Standard | 5.5-4000pg/mL | Nature Human cTnI Protein |
