Overview
| Product name | Biotinylated Recombinant Cynomolgus FcRn/FCGRT&B2M Protein |
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| Catalog No. | RP02363B |
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| Description | Biotinylated Recombinant Cynomolgus FcRn/FCGRT&B2M Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Met1-Ser297(FCGRT)&Met1-Met119(B2M)) of Cynomolgus FcRn fused with a His tag and Avi tag at the C-terminal . |
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| Purity | > 95% by Tris-Bis PAGE;> 95% by SEC-HPLC |
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| Endotoxin | < 1 EU/μg of the protein by LAL method. |
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| Formulation | Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. |
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| Species | Cynomolgus |
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| Calculated MW | 46.5 kDa |
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Background
The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer.
Product information
| Synonym | FcRn alpha chain; alpha-chain; Fc fragment of IgG; receptor; transporter; alpha; FCGRT; FCRN; FCRNimmunoglobulin receptor; intestinal; heavy chain; IgG Fc fragment receptor transporter alpha chain; IgG receptor FcRn large subunit p51; major histocompatibil |
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| Expression Host | HEK293 cells |
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| Tag | C-His&Avi |
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| Swiss-Prot | |
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| Gene ID | |
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Usage guide
| Storage | Store at -20℃. Store the lyophilized protein at -20℃ to -80℃ up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
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| Reconstitution | Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. |
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* For research use only. Not for therapeutic or diagnostic purposes.
