Overview
| Product name | Recombinant Human CCL5/RANTES Protein |
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| Catalog No. | RP01611LQ |
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| Description | Recombinant Human CCL5/RANTES Protein is produced by Pichia expression system. The target protein is expressed with sequence (Ser24-Ser91) of human CCL5/RANTES (Accession #NP_002976.2) fused with a 6×His tag at the C-terminus. |
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| Bio-Activity | Measured by its binding ability in a functional ELISA. Immobilized Human CCL5 (Catalog: RP01611LQ) at 2 μg/mL (100 μL/well) can bind Mouse CXCL4(Catalog: RP03170) with a linear range of 41.2-815 ng/mL.
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| Purity | > 95% by SDS-PAGE. |
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| Endotoxin | <0.1EU/μg |
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| Formulation | Supplied as a 0.22 μm filtered solution in PBS, pH 7.4. |
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| Species | Human |
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| Calculated MW | 8.69 kDa |
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Background
Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.
Product information
| Synonym | D17S136E; eoCP; RANTES; SCYA5; SIS-delta; SISd; TCP228; CCL5 |
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| Expression Host | Pichia |
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| Tag | C-His |
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| Swiss-Prot | |
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| Gene ID | |
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Usage guide
| Storage | Store at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
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* For research use only. Not for therapeutic or diagnostic purposes.
