Overview
| Product name | Recombinant Human FKBP1A/FKBP12 Protein |
|---|
| Catalog No. | RP00051 |
|---|
| Description | Recombinant Human FKBP1A/FKBP12 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Glu108) of human FKBP12 (Accession #NP_000792.1). |
|---|
| Purity | > 90% by SDS-PAGE. |
|---|
| Endotoxin | < 0.1 EU/μg of the protein by LAL method. |
|---|
| Formulation | Lyophilized from a 0.22 μm filtered solution of 20mM Tris, 150mM NaCl, pH 8.0.Contact us for customized product form or formulation. |
|---|
| Species | Human |
|---|
| Calculated MW | 11.95 kDa |
|---|
Background
The protein is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor.
Product information
| Synonym | FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12; PKCI2; PPIASE; FKBP1A; FKBP-1A; FKBP1; FKBP12; PKC12; PKCI2; PPIASE |
|---|
| Expression Host | E. coli |
|---|
| Tag | No tag |
|---|
| Swiss-Prot | |
|---|
| Gene ID | |
|---|
Usage guide
| Storage | Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
|---|
| Reconstitution | Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. |
|---|
* For research use only. Not for therapeutic or diagnostic purposes.
