Overview
| Product name | Recombinant Human IL-17C Protein |
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| Catalog No. | RP02709 |
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| Description | Recombinant Human IL-17C Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (His19-Val197) of Human IL-17C (Accession #NP_037410.1) fused with a His tag at the C-terminus. |
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| Purity | > 95% by SDS-PAGE.；> 95% as determined by SEC-HPLC |
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| Endotoxin | <0.01EU/μg by the LAL method. |
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| Species | Human |
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| Calculated MW | 20.58 kDa |
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Background
Interleukin 17C (IL-17C) is a 15-20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL-17 cytokines (IL?17A?F) are encoded by separate genes but adopt a conserved cystine knot fold. IL?17C is Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G.
Product information
| Synonym | CX2; Cytokine CX2; IL17C; IL-17C; IL-17CMGC126884 |
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| Expression Host | HEK293 cells |
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| Tag | C-His |
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| Swiss-Prot | |
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| Gene ID | |
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Usage guide
| Storage | Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
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| Reconstitution | Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. |
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* For research use only. Not for therapeutic or diagnostic purposes.
