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Recombinant Human Insulysin/IDE Protein (RP03201LQ)

Datasheet

Overview

Product nameRecombinant Human Insulysin/IDE Protein
Catalog No.RP03201LQ
DescriptionRecombinant Human Insulysin/IDE Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Met42-Leu1019) of Human Insulysin/IDE (Accession #P14735) fused with His tag at the C-terminus.
Purity> 95% by SDS-PAGE.
Endotoxin< 1.0 EU/μg of the protein by LAL method.
FormulationSupplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 15 0mM NaCl, 0.05% Brij35, 10% Glycerol, pH 7.5.
SpeciesHuman
Calculated MW114.25 kDa
Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted amyloid β-protein by neurons and microglia. IDE, which migrates at 110 kDa during gel electrophoresis under denaturing conditions, has since been shown to have additional substrates, including the signaling peptides glucagon, TGF α and β-endorphin.
SynonymInsulin-Degrading Enzyme; Abeta-Degrading Protease; Insulin Protease; Insulinase; Insulysin; IDE
Expression HostHEK293 cells
TagC-His
Swiss-Prot
Gene ID
StorageStore at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles.

* For research use only. Not for therapeutic or diagnostic purposes.

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