Overview
| Product name | Recombinant Human MetAP1 Protein |
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| Catalog No. | RP03202LQ |
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| Description | Recombinant Human MetAP1 Protein is produced by E.coli expression system. The target protein is expressed with sequence (Met1-Phe386) of human MetAP1 (Accession #P53582) fused with No tag. |
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| Purity | > 95% by SDS-PAGE. |
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| Endotoxin | < 1.0 EU/μg of the protein by LAL method. |
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| Formulation | Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 500 mM NaCl, 10% Glycerol, pH 8.0. |
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| Species | Human |
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| Calculated MW | 43.2 kDa |
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Background
Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs.
Product information
| Synonym | Methionine aminopeptidase 1; MAP 1; MetAP 1; Peptidase M 1; METAP1 |
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| Expression Host | E.coli |
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| Tag | No tag |
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| Swiss-Prot | |
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| Gene ID | |
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Usage guide
| Storage | Store at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
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* For research use only. Not for therapeutic or diagnostic purposes.
