Overview
| Product name | Recombinant Human PMKase/PMVK Protein |
|---|
| Catalog No. | RP02879LQ |
|---|
| Description | Recombinant Human PMKase/PMVK Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Leu192) of human PMKase/PMVK (Accession #NP_006547.1) fused with a 6×His tag at the N-terminus. |
|---|
| Purity | > 95% as determined by SDS-PAGE. |
|---|
| Endotoxin | <1EU/μg |
|---|
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, 10% Glycerol, pH 7.5. |
|---|
| Species | Human |
|---|
| Calculated MW | 24.2 kDa |
|---|
Background
Phosphomevalonate kinase (PMVK) is a cytosolic enzyme. PMVK can be highly expressed in the heart, skeletal muscle, liver, pancreas, and kidney; it is expressed at lower levels in the brain, lung, and placenta. Induced by sterol, PMVK takes part in isopentenyl diphosphate biosynthesis through the mevalonate pathway. PMVK catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate in the fifth reaction of the cholesterol biosynthetic pathway.
Product information
| Synonym | PMVK; HUMPMKI; PMK; PMKA; PMKASE; POROK1 |
|---|
| Expression Host | E. coli |
|---|
| Tag | N-His |
|---|
| Swiss-Prot | |
|---|
| Gene ID | |
|---|
Usage guide
| Storage | Store at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
|---|
* For research use only. Not for therapeutic or diagnostic purposes.
