Overview
| Product name | Recombinant Mouse FGFR-4/CD334 Protein |
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| Catalog No. | RP01469 |
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| Description | Recombinant Mouse FGFR-4/CD334 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu17-Asp366) of mouse FGFR4/FGF Receptor 4 (Accession #NP_032037.2) fused with a 6×His tag at the C-terminus. |
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| Bio-Activity | Measured by its ability to inhibit FGF acidic-dependent proliferation of Balba3T3 mouse fibroblast cells.The ED50 for this effect is 38.74-154.96 ng/mL in the present of mouse FGF-1/aFGF(Catalog: RP00487), corresponding to a specific activity of 6.45×103~2.58×104 units/mg.
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| Purity | > 95% by SDS-PAGE. |
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| Endotoxin | < 0.1 EU/μg of the protein by LAL method. |
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| Formulation | Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. |
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| Species | Mouse |
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| Calculated MW | 39.65 kDa |
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Background
The protein is a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described.
Product information
| Synonym | Fgfr-4; FGFR4; CD334; JTK2; MGC20292; TKF; FGFR4; Fgfr-4; FGFR4; CD334; JTK2; MGC20292; TKF; FGFR4 |
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| Expression Host | HEK293 cells |
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| Tag | C-His |
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| Swiss-Prot | |
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| Gene ID | |
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Usage guide
| Storage | Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
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| Reconstitution | Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. |
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* For research use only. Not for therapeutic or diagnostic purposes.
