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Recombinant Mouse Fc-gamma RIII/CD16 Protein (RP00761)

Publication (1) Datasheet

Overview

Product nameRecombinant Mouse Fc-gamma RIII/CD16 Protein
Catalog No.RP00761
DescriptionRecombinant Mouse Fc-gamma RIII/CD16 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Ala31-Thr215) of mouse Fc γ RIIIA/FCGR3/CD16 (Accession #P08508) fused with a 6×His tag at the C-terminus.
Purity> 95% by SDS-PAGE.
Endotoxin< 1 EU/μg of the protein by LAL method.
FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.
SpeciesMouse
Calculated MW22 kDa
Low affinity immunoglobulin gamma Fc region receptor III (Fc gamma RIII/CD16) is a member of the Igsuperfamily. Based on close relationships in their extracellular domains, the Fc gamma Rs have been dividedinto three classes composing of Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Eachgroup may be encoded by multiple genes and exist in different isoforms depending on species and cell type.Mouse CD16 is a type I transmembrane protein having two extracellular Ig-like domains consisting ofimmunoglobulin domain, repeat, signa and transmembrane, transmembrane helix. It is expressed on a varietyof myeloid and lymphoid cells and associates with Fc R gamma to deliver an activating signal upon ligandbinding. Fcgr3 is IgG binding and activation or inhibition of immune responses such as antibody-dependentcellular cytotoxicity, phagocytosis, cell surface receptor signaling pathway and positive regulation of typeI/IIa/III hypersensitivity.
SynonymLow affinity immunoglobulin gamma Fc region receptor III; Fcgr3; Fc gamma Receptor III; CD-antigen 16; CD16; FcRIII; IgG Fc receptor III
Expression HostHEK293 cells
TagC-His
Swiss-Prot
Gene ID
StorageStore at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
ReconstitutionCentrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

* For research use only. Not for therapeutic or diagnostic purposes.

Publishing research using RP00761? Please let us know so that we can cite the reference in this datasheet.

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