Overview
| Product name | Recombinant Mouse Hepcidin/HAMP Protein |
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| Catalog No. | RP02870LQ |
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| Description | Recombinant Mouse Hepcidin/HAMP Protein is produced by E. coli expression system. The target protein is expressed with sequence (Asp59-Thr83) of mouse Hepcidin/HAMP (Accession #NP_115930.1) fused with GST tag at the N-terminus. |
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| Purity | > 95% as determined by HPLC. |
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| Endotoxin | <1EU/μg |
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| Formulation | Supplied as a 0.22 μm filtered solution in 50 mM Tris-HCl, 150 mM NaCl, 2 mM DTT, pH 7.5. |
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| Species | Mouse |
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| Calculated MW | 29.05 kDa |
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Background
Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.
Product information
| Synonym | Hamp1; Hepc; Hepc1; HFE2B; LEAP1; LEAP-1; PLTR |
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| Expression Host | E. coli |
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| Tag | N-GST |
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| Swiss-Prot | |
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| Gene ID | |
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Usage guide
| Storage | Store at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
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* For research use only. Not for therapeutic or diagnostic purposes.
