Neurotrophy
Neurobiology is a science that studies the structure, function, and related diseases of the nervous system, including the brain, spinal cord, and peripheral nervous system. Understanding the organization and functioning of the brain and nervous system is crucial for uncovering the causes of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). By using reliable research tools provided by ABclonal, it is possible to delve deeply into the mechanisms that lead to these diseases, including the molecular and cellular events related to the structure and function of different cell types in the brain, such as neurons, microglia, oligodendrocytes, and astrocytes.
Cell Metabolism
Cell metabolism refers to the total set of ordered chemical reactions that occur within cells to sustain life. These processes enable organisms to grow, reproduce, maintain structure, and respond to external environments. Metabolic abnormalities are implicated in a variety of diseases, such as diabetes, non-alcoholic fatty liver disease, hypertension, heart disease, obesity, cancer, and neurodegenerative disorders. Currently, the field of cell metabolism research is vast, with key areas of focus including nutrient-sensing signaling pathways and regulatory molecules, metabolic enzymes involved in glucose, lipid, and amino acid metabolism, as well as critical molecules and signaling pathways involved in redox regulation and metabolism-related cellular stress responses.
Epigenetics
Epigenetics is a branch of genetics that studies reversible modifications of nucleotides or histones without altering the DNA sequence. Epigenetics encompasses a wide range of research topics, including histone modifications, histone-modifying enzymes, transcription factor regulation, DNA methylation, RNA modifications, and various research methods such as WB (Western blot), IP (immunoprecipitation), ChIP (chromatin immunoprecipitation), as well as high-throughput techniques like ChIP-seq and CUT&Tag.
SMab ™ Recombinant Rabbit Monoclonal Antibody
SMab™Recombinant Rabbit Monoclonal Antibody A NOVEL SINGLE B-CELL BASED PLATFORMFOR MONOCLONAL ANTIBODY Compared with traditional rabbit polyclonal antibodies and mouse monoclonal antibodies, rabbit monoclonal antibodies have significant advantages, including strong specificity, high affinity, stable product quality, and high batch-to-batch consistency. In addition, rabbits have a unique immune system that can recognize more abundant epitopes, making them more suitable than mice for producing antibodies to small molecules and modified antigens.ABclonal employs unique cell sorting and enrichment techniques to isolate and culture single positive B cells in vitro. Through bioinformatics analysis, the coding sequences of antibodies from positive B cells are obtained. Finally, the required antibodies are expressed using a mammalian cell expression system. The produced antibodies undergo various application tests to ensure reliable quality, meeting the needs of both research and industrial sectors.
Programmed Cell Death
Programmed cell death (PCD) is a cell death process mediated by specific molecular programs regulated by genes within cells. It plays a crucial role in the normal development of multicellular organisms and the maintenance of homeostasis in the body. Current programmed cell death pathways include apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis and cuproptosis.
Flow Cytometry Antibodies
Flow Cytometry (FCM) is a widely-used method that utilizes a flow cytometer to conduct simultaneous multi-parameter qualitative and quantitative analysis, and sorting of cells or particles in a rapid linear flow state under specific wavelength laser irradiation.
Tumor Immunology
Tumor immunology is a discipline that studies the relationship between tumor antigens, immune function, and tumor development and prognosis. It encompasses basic research on host-tumor interactions, developmental therapy in model systems, early patient transformation studies, and late-stage clinical trials, with the ultimate goal of developing tumor treatment methods.. The direction of tumor immunology research varies according to the type of tumor, encompassing endogenous anti-tumor immunity, tumor microenvironment, pro-tumor inflammation, cancer antigens, vaccines, cell therapy, cytokines, immune regulation, immune suppression, and comprehensive immune modulation in cancer treatment.
