| Product name | Rabbit anti-Human CD40 mAb (DET) |
|---|---|
| Catalog No. | RM17916 |
| Catagory | Elisa Antibody Kit |
| Application | ELISA |
| Description | This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
| Immunogen | Recombinant Human CD40 |
| Purirty | Affinity purification |
| Ig Type | Rabbit IgG |
| Formulation | Supplied as a 0.2um filtered solution in PBS with 0.05%ProClin 300, PH 7.4. |
| CrossReactivity | No cross-reactivity in ELISA assay withrecombinant Human. sCD40L，Human.TNF R1 |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. Preservative：0.05%ProClin 300. Avoid repeated freeze-thaw cycles. |
Human CD40 Sandwich ELISA Immunoassay
| Recommended Concentration | Sample | |
|---|---|---|
| ELISA Capture | 1-4ug/mL | Rabbit anti-Human CD40 (CAP)(Cat. No.RM17915) |
| ELISA Detection | 0.025-0.00625ug/mL | Rabbit anti-Human CD40 (DET)(Cat. No.RM17916) |
| Standard | 15.63-1000pg/mL | Recombinant Human CD40 Protein(Cat. No.RP01214) |
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