Overview
| Product name | Recombinant Human Asparaginyl endopeptidase/Legumain/LGMN Protein |
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| Catalog No. | RP03221LQ |
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| Description | Recombinant Human Asparaginyl endopeptidase/Legumain/LGMN Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Ile18-Tyr433) of Human Asparaginyl endopeptidase/Legumain/LGMN (Accession #AAH03061.1) fused with His tag at the C-terminus. |
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| Purity | > 95% by SDS-PAGE. |
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| Endotoxin | < 1.0 EU/μg of the protein by LAL method. |
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| Formulation | Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 10% Glycerol, pH 8.0. |
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| Species | Human |
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| Calculated MW | 48.72 kDa |
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Background
Legumain is a lysosomal cysteine protease which is a member of the peptidase C13 family. Though it is found in many tissues, it is highly expressed in the kidney, heart, and placenta. Legumain has a strict specificity for hydrolysis of asparaginyl bonds and can also cleave aspartyl bonds slowly, especially under acidic conditions. Over-expression Legumain in tumors is significant for invasion and metastasis. In addition, Legumain may be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system and negative regulation of neuron apoptosis.
Product information
| Synonym | Legumain; Asparaginyl Endopeptidase; Protease Cysteine 1; LGMN; PRSC1 |
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| Expression Host | HEK293 cells |
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| Tag | C-His |
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| Swiss-Prot | |
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| Gene ID | |
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Usage guide
| Storage | Store at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
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* For research use only. Not for therapeutic or diagnostic purposes.
