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Recombinant Human Atrophin-1 interacting protein 4/ITCH protein (RP10137LQ)

Datasheet

Overview

Product nameRecombinant Human Atrophin-1 interacting protein 4/ITCH protein
Catalog No.RP10137LQ
DescriptionRecombinant Human Atrophin-1 interacting protein 4/ITCH protein is produced by E. coli expression system. The target protein is expressed with sequence (Ser2-Glu903) of Human Atrophin-1 interacting (Accession #NP_001244066.1) fused with no tag.
Purity≥ 90 % as determined by SDS-PAGE
Endotoxinplease contact us for more information.
Formulation0.22 μm filtered solution of PBS, pH 7.4.
SpeciesHuman
Calculated MW102.67 KDa
ITCH, also called atrophin-1 interacting protein 4 (AIP4), is a HECT-type E3 ubiquitin ligase. It contains an N-terminal Ca-dependent phospholipid-binding C2 domain, four WW domains, and a C-terminal HECT domain. Mice deficient in ITCH protein display many autoimmune-like disease characteristics such as lymphoproliferation in the spleen and lymph nodes. More than a dozen of substrates of ITCH have been identified including p63, p73 and Notch1. The ligase may be responsible for ubiquitinating proteins with K29-, K48-, and/or K63-linked ubiquitin chains.
SynonymITCH; E3 ubiquitin-protein ligase Itchy homolog; Itch; EC:2.3.2.26; Atrophin-1-interacting protein 4; AIP4; HECT-type E3 ubiquitin transferase Itchy homolog; NFE2-associated polypeptide 1; NAPP1
Expression HostE. coli
TagNO-Tag
Swiss-Prot
Gene ID
StorageStore at -70°C. This product is stable at ≤ -70°C for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles.

* For research use only. Not for therapeutic or diagnostic purposes.

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