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Recombinant Human Gamma-glutamyl hydrolase/GGH Protein (RP03146)

Datasheet

Overview

Product nameRecombinant Human Gamma-glutamyl hydrolase/GGH Protein
Catalog No.RP03146
DescriptionRecombinant Human Gamma-glutamyl hydrolase/GGH Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Arg25-Asp318) of Human Gamma-glutamyl hydrolase/GGH (Accession #NP_003869.1) fused with a 6×His tag at the C-terminus.
Purity> 95% by SDS-PAGE.
Endotoxin< 1 EU/μg of the protein by LAL method.
FormulationLyophilized from a 0.22 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0. Contact us for customized product form or formulation.
SpeciesHuman
Calculated MW35.1 kDa.
gamma-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. GGH is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer.
SynonymGamma-glutamyl hydrolase; GGH; Gamma-Glu-X carboxypeptidase
Expression HostHEK293 cells
TagC-His
Swiss-Prot
Gene ID
StorageStore at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
ReconstitutionCentrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

* For research use only. Not for therapeutic or diagnostic purposes.

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