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Recombinant Human HGK2/DDR1/CD167a Protein (RP01488LQ)

Bioactivityvalidated

Datasheet

Overview

Product nameRecombinant Human HGK2/DDR1/CD167a Protein
Catalog No.RP01488LQ
DescriptionRecombinant Human HGK2/DDR1/CD167a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp21-Ala417) of human DDR1 (Accession #NP_054699.2) fused with a 6×His tag at the C-terminus.
Bio-ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human DDR1 at 1 μg/mL (100 μL/well) can bind DDR1 Rabbit pAb with a linear range of 0.24-44.7 ng/mL.
Purity> 95% by SDS-PAGE.
Endotoxin<0.1EU/μg
FormulationSupplied as a 0.22 μm filtered solution in PBS, pH 7.4.Contact us for customized product form or formulation.
SpeciesHuman
Calculated MW44.87 kDa
Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.
SynonymCAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE; DDR1
Expression HostHEK293 cells
TagC-His
Swiss-Prot
Gene ID
StorageStore at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles.
ReconstitutionReconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

* For research use only. Not for therapeutic or diagnostic purposes.

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