Overview
| Product name | Recombinant Human MMP-3 Protein |
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| Catalog No. | RP00220LQ |
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| Description | Recombinant Human MMP-3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Tyr18-Cys477) of human MMP-3 (Accession #NP_002413.1) fused with a 6×His tag at the C-terminus. |
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| Bio-Activity | Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The specific activity is >515 pmol/min/μg.
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| Purity | > 92% by SDS-PAGE. |
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| Endotoxin | < 0.1 EU/μg of the protein by LAL method. |
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| Formulation | Supplied as a 0.22 μm filtered solution in 20mM Tris, 150mM NaCl, 0.05% Brij-35 (w/v), 10% Glycerol, pH 7.5.Contact us for customized product form or formulation. |
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| Species | Human |
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| Calculated MW | 53.06 kDa |
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Background
Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase.MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.
Product information
| Synonym | CHDS6; MMP-3; SL-1; STMY; STMY1; STR1; MMP3; MMP-3; SL-1; STMY; STMY1; STR1 |
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| Expression Host | HEK293 cells |
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| Tag | C-His |
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| Swiss-Prot | |
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| Gene ID | |
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Usage guide
| Storage | Store at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
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* For research use only. Not for therapeutic or diagnostic purposes.
