Recombinant mouse IFN-alpha 2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Cys24-Glu191) of mouse IFN-alpha 2 (Accession #) fused with additional amino acid free.
Interferon-alpha 2 (IFN alpha -2) is one of 14 subtypes within the IFN-alpha class of Type?I Interferons (1). The members of the IFN-alpha class, also known as alpha leukocyte interferons, encompass a group of distinct but closely related proteins which share approximately 80%?amino acid (aa) sequence identity and have a similar globular structure composed of five alpha-helices (1, ?3, ?4). IFN-alpha class members signal through a common cell surface receptor complex composed of IFN-alpha R2 and IFN-alpha R1 subunits (3). As the first highly active IFN to be cloned and produced, IFN alpha -2 has become the prototypic IFN for academic and pharmaceutical research (2). The mature extracellular domain (ECD) of mouse IFN alpha -2 shares 60%?and 83%?aa sequence identity with human and rat, respectively. Murine IFN-alpha 2 can eliminate cardiac viral load and protect cardiomyocytes from injury in animals infected with coxsackievirus B3 (CVB3) (5). IFN alpha -2 derived mutants with reduced IFNR2 binding inhibited HIV replication and mutants with more IFNAR1 binding potentiated antiviral activity (6)
Store at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles.
Reconstitution
0.2 mg/mL in sterile PBS, pH7.4
* For research use only. Not for therapeutic or diagnostic purposes.
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