Recombinant Mouse IL-17A/CTLA-8 Protein (RP02520)

Overview

Product name	Recombinant Mouse IL-17A/CTLA-8 Protein
Catalog No.	RP02520
Description	Recombinant Mouse IL-17A Protein is produced by Escherichia coli expression system. The target protein is expressed with sequence of Mouse IL-17A fused with polyhistidine tag at the C-terminus
Bio-Activity	Measured by its ability to inhibit IL-6 secretion in 3T3 cells. The ED₅₀ for this effect is <1 ng/mL. The specific activity of recombinant mouse IL-17A is > 1 x 106 IU/mg.
Purity	> 98% by SDS-PAGE.
Endotoxin	<0.1EU/μg
Formulation	Lyophilized from a 0.22 μm filtered solution of 20 mM sodium citrate, 0.2 M NaCl, pH 4.5.
Species	Mouse

Interleukin-17A is a protein that in humans is encoded by the IL17A gene. The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).

Product information

Synonym	Il17; Ctla8; IL-17; Ctla-8; IL-17A; IL17A; il17a
Expression Host	E. coli
Tag	C-His
Swiss-Prot
Gene ID

Usage guide

Storage	Store the lyophilized protein at -20°C to -80°C for long term. After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Reconstitution	Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

* For research use only. Not for therapeutic or diagnostic purposes.