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Human IL-6R Monoclonal Antibody (YR0003)

Datasheet

ABclonal: - Human IL-6R Monoclonal Antibody (YR0003)

Direct ELISA binding curve demonstrating the recognition of Human Anti-Human IL-6RA (Research Grade Tocilizumab Biosimilar) Monoclonal Antibody to IL-6RA. The target protein was coated onto the microplate well surface, followed by binding of the antibody. A donkey anti-human IgG HRP conjugate was used for detection.

ABclonal: - Human IL-6R Monoclonal Antibody (YR0003)

Human IL-6RA SPR assay. Determined through SPR assay, the Human Anti-Human IL-6RA (Research Grade Tocilizumab Biosimilar) Monoclonal Antibody is capable of binding to Human IL-6RA with an affinity constant of 1.847 nM.

Basic Information

CloneTocilizumab Biosimilar
Molecular Weight150 kDa
Endotoxin<1EU/mg (<0.001EU/μg)Determined by LAL gel clotting assay
Sterility0.2 μm filtration
Aggregation<5% Determined by SECP
Purity>95% Determined by SEC-HPLC
ProductionPurified from cell culture supernatant in an animal-free facility
PurificationProtein A or G purification
Storage2 - 8°C for up to 4 weeks and -80°C for long term storage (Avoid repeated freezing and thawing)
What is tocilizumab biosimilar research grade? Tocilizumab biosimilar uses the same protein sequences as the therapeutic antibody tocilizumab. Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. Interleukin 6 (IL-6) is a pro-inflammatory cytokine produced by cells including T-cells, B-cells, lymphocytes, monocytes, fibroblasts. IL-6 rapidly induces C-reactive protein, serum amyloid A, fibrinogen, haptoglobin, and α-1-antichymotrypsin while inhibiting production of fibronectin, albumin, and transferrin. IL-6 also induces antibody production, induces cytotoxic T-cell differentiation, and inhibits regulatory T-cell differentiation. Tocilizumab binds soluble and membrane bound IL-6 receptors, preventing IL-6 mediated inflammation.
Isotypehuman IgG1 kappa
ImmunogenHuman IL-6R
RecommendedIsotype Control(s)In Vivo Grade Recombinant Human IgG1 Kappa Isotype Control Antibody
Recommended Dilution Buffer1×PBS pH 7.0
ABclonal: - Human IL-6R Monoclonal Antibody (YR0003)}

- Human IL-6R Monoclonal Antibody (YR0003)

Direct ELISA binding curve demonstrating the recognition of Human Anti-Human IL-6RA (Research Grade Tocilizumab Biosimilar) Monoclonal Antibody to IL-6RA. The target protein was coated onto the microplate well surface, followed by binding of the antibody. A donkey anti-human IgG HRP conjugate was used for detection.
ABclonal: - Human IL-6R Monoclonal Antibody (YR0003)}

- Human IL-6R Monoclonal Antibody (YR0003)

Human IL-6RA SPR assay. Determined through SPR assay, the Human Anti-Human IL-6RA (Research Grade Tocilizumab Biosimilar) Monoclonal Antibody is capable of binding to Human IL-6RA with an affinity constant of 1.847 nM.

* For research use only. Not for therapeutic or diagnostic purposes.