| Product name | Rabbit anti-Human sST2 mAb(CAP) |
|---|---|
| Catalog No. | RM17778 |
| Catagory | Elisa Antibody Kit |
| Application | ELISA |
| Description | Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization |
| Immunogen | Recombinant Human sST2 Protein |
| Purirty | Affinity purification |
| Ig Type | Rabbit IgG |
| Formulation | Supplied as a 0.2μm filtered solution in PBS with 0.05% Proclin300, PH 7.4. |
| CrossReactivity | No significant cross-reactivity or interference between sST2 and analogues was observed. |
| Storage | Store at -20℃. Avoid repeated freeze-thaw cycles. |
Human sST2 Sandwich Immunoassay
| Recommended Concentration | Sample | ||
|---|---|---|---|
| ELISA | Capture | 1-4ug/mL | Rabbit anti-Human sST2 mAb(Cat. No.RM17778) |
| Detection | 0.015-0.06ug/mL | Rabbit anti-Human sST2 mAb(Cat. No.RM17779) | |
| Standard | 7.8-500pg/mL | Recombinant Human sST2 Protein |
