Biotinylated Recombinant Human Siglec-5/CD170 Protein (Primary Amine Labeling) (RP00358B)

Overview

Product name	Biotinylated Recombinant Human Siglec-5/CD170 Protein (Primary Amine Labeling)
Catalog No.	RP00358B
Description	Biotinylated Recombinant Human Siglec-5/CD170 Protein (Primary Amine Labeling) is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu17-Thr434) of Human Siglec-5/CD170 (Primary Amine Labeling) (Accession #O15389) fused with a C-hFc tag at the C-terminus.
Purity	> 95% by SDS-PAGE
Endotoxin	< 1 EU/μg of the protein by LAL method
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Species	Human
Calculated MW	73.1 kDa

Group B Streptococcus (GBS) causes invasive infections in human newborns. the GBS β-protein attenuates innate immune responses by binding to sialic acid-binding immunoglobulin-like lectin 5 (Siglec-5), an inhibitory receptor on phagocytes.the polymorphism could influence the risk of prematurity among human fetuses of mothers colonized with GBS. This first functionally proven example of a paired receptor system in the Siglec family has multiple implications for regulation of host immunity.

Product information

Synonym	CD170; CD33 antigen-like 2; CD33L2; OBBP2; Siglec5; SIGLEC5; OB-BP2
Expression Host	HEK293 cells
Tag	C-hFc
Swiss-Prot
Gene ID

Usage guide

Storage	Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Reconstitution	Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

* For research use only. Not for therapeutic or diagnostic purposes.