Biotinylated Recombinant Human TNFRSF10B/DR5/TRAIL-R2/CD262 Protein (RP02085B)

Overview

Product name	Biotinylated Recombinant Human TNFRSF10B/DR5/TRAIL-R2/CD262 Protein
Catalog No.	RP02085B
Description	Biotinylated Recombinant Human TNFRSF10B/DR5/TRAIL-R2/CD262 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Ile56-Glu182) of Human TNFRSF10B/DR5/TRAIL-R2/CD262 fused with His tag and Avi tag at the C-terminus.
Purity	> 95% by Tris-Bis PAGE and HPLC
Endotoxin	< 1 EU/μg of the protein by LAL method.
Formulation	Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.
Species	Human
Calculated MW	17.2 kDa

DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

Product information

Synonym	CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9; TNFRSF10B
Expression Host	HEK293 cells
Tag	C-His&Avi
Swiss-Prot
Gene ID

Usage guide

Storage	Store at -20℃. Store the lyophilized protein at -20℃ to -80℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Reconstitution	Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

* For research use only. Not for therapeutic or diagnostic purposes.