Overview
| Product name | Recombinant Human Claudin-4 Protein |
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| Catalog No. | RP02997LQ |
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| Description | Recombinant Human Claudin-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Val209) of human Claudin-4 (Accession #NP_001296.1 ) fused with no additional amino acid. |
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| Bio-Activity | Immobilized Human Claudin-4 VLP at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 18.4ng/ml determined by ELISA.
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| Purity | > 95% as determined by HPLC |
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| Endotoxin | Less than 1EU per μg by the LAL method. |
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| Formulation | Supplied as 0.22μm filtered solution in PBS (pH 7.4). Notice: If you need it for immunization, Do Not use any adjuvant. |
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| Species | Human |
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| Calculated MW | 23.31 kDa |
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Background
Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.
Product information
| Synonym | Claudin-4; CLDN4; Claudin4; CPE-R; CPE R; CPETR1; WBSCR8 |
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| Expression Host | HEK293 cells |
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| Tag | No tag |
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| Swiss-Prot | |
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| Gene ID | |
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Usage guide
| Storage | Store at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
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* For research use only. Not for therapeutic or diagnostic purposes.
