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Recombinant Mouse IFN-beta Protein (RP01883)

Datasheet

Overview

Product nameRecombinant Mouse IFN-beta Protein
Catalog No.RP01883
DescriptionRecombinant Mouse IFN-beta Protein is produced by Pichia expression system. The target protein is expressed with sequence (Ile 22 -Asn 182) of Mouse IFN-beta (Accession #NP_034640.1) fused with no tag.
Endotoxin<0.1EU/μg of the protein by LAL method.
FormulationLyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
SpeciesMouse
Calculated MW19.73 kDa
Interferon beta (IFN-beta ), also known as fibroblast IFN, is a secreted, approximately 22 kDa member of the type I interferon family of molecules . Mature mouse IFN-beta shares 75% and 47% amino acid sequence identity with the rat and human proteins, respectively. Fibroblasts are the major producers of IFN-beta, but it can also be produced by dendritic cells, macrophages, and endothelial cells in response to pathogens . It is transcriptionally regulated by TRAF3, IRF3, IRF7, and NF-kappa B . IFN-beta -deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS) . Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS . IFN-beta can additionally induce the expression of the anti-inflammatory cytokine IL-10 .
SynonymIfnb1; Ifb; Ifnb; Interferon beta; IFN-beta
Expression HostPichia
TagNo-tag
Swiss-Prot
Gene ID
StorageStore at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
ReconstitutionCentrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

* For research use only. Not for therapeutic or diagnostic purposes.

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