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Rabbit anti-Human IgM mAb (RMK0354)

Datasheet

ABclonal: - Rabbit anti-Human IgM mAb (RMK0354)

Overview

Product nameRabbit anti-Human IgM mAb
Catalog No.RMK0354
CatagoryElisa Antibody Kit
Applicationmultiplex assay
DescriptionImmunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).
ImmunogenHuman IgM
PurirtyAffinity purification
Ig TypeRabbit IgG
FormulationSupplied as a 0.2um filtered solution in PBS, PH 7.4 containing Human IgM Antibody
CrossReactivity/
StorageStore at -20℃. Avoid freeze / thaw cycles. Preservative:0.05%ProClin 300.

Avoid repeated freeze-thaw cycles.

Application

Human IgM multiplex assay

 Recommended
Concentration
Sample
Multiplex Capture3-20ug/mLRabbit anti-Human IgM mAb(Cat. No.RMK0353)
Multiplex Detection0.017-2ug/mLRabbit anti-Human IgM mAb(Cat. No.RMK0354)
Standard6.86-5000pg/mLRecombinant Human IgM Protein
ABclonal: - Rabbit anti-Human IgM mAb (RMK0354)}

- Rabbit anti-Human IgM mAb (RMK0354)

Standard Curve Chart
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