Overview
Product name | Recombinant Human DNMT3A Protein |
---|
Catalog No. | RP01971LQ |
---|
Background
DNMT3A, as de novo DNA methyltransferase, is essential for regulating gene expression through cellular development and differentiation.IT Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development .It modifies DNA in a non-processive manner and also methylates non-CpG sites . The functions of DNMT3A rely on its oligomeric states and allosteric regulations between its catalytic domain and binding partners. DNMT3A variants are present in elderly healthy individuals and patients with AML in complete remission, which suggests that DNMT3A mutations may contribute to pre-leukemic clonal hematopoiesis.
Product information
Synonym | DNMT3A; DNA (cytosine-5)-methyltransferase 3A; Dnmt3a; Cysteine methyltransferase DNMT3A; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA |
---|
Expression Host | HEK293 cells |
---|
Swiss-Prot | |
---|
Gene ID | |
---|
Usage guide
Storage | Store at -70°C. This product is stable at ≤ -70°C for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
---|
* For research use only. Not for therapeutic or diagnostic purposes.