AMP-activated protein kinase (AMPK), an important serine/threonine protein kinase that plays a key role in coordinating metabolism and energy. It is the core to studying diabetes and other metabolic diseases. AMPK is expressed in a variety of metabolic-related organs and can be activated by various stimuli including cellular stress, exercise, and many hormones and substances that affect cell metabolism. AMPK proteins from different species all exist in the form of a heterotrimer complex consisting of an α-catalytic subunit, a β-regulatory subunit, and a γ-regulatory subunit.
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