| Product name | Rabbit anti-Human IL-1 beta mAb |
|---|---|
| Catalog No. | RMK0033 |
| Catagory | Elisa Antibody Kit |
| Application | ELISA |
| Description | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 117-269 of human IL-1β (NP_000567.1). |
| Purirty | Affinity purification |
| Ig Type | Rabbit IgG |
| Formulation | Supplied as a 0.2um filtered solution in PBS with 0.05%ProClin 300, PH 7.4. |
| CrossReactivity | / |
| Storage | Store at -20℃. Avoid repeated freeze-thaw cycles. |
Human IL-1 beta Sandwich Immunoassay
| Recommended Concentration | Sample | ||
|---|---|---|---|
| ELISA | Capture | 1-4 ug/mL | Rabbit anti-Human IL-1 beta mAb(Cat. No.RMK0033) |
| Detection | 0.125-0.5ug/mL | Rabbit anti-Human IL-1 beta mAb(Cat. No.RMK0034) | |
| Standard | 0.625-40pg/mL | Recombinant Human IL-1 beta Protein(Cat. No.RP00002) |
