| Product name | Rabbit anti-Human IL-2R mAb |
|---|---|
| Catalog No. | RM17893 |
| Catagory | Elisa Antibody Kit |
| Application | CLIA |
| Description | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 22-213 of human IL-2R(NP_000408.1) |
| Purirty | Affinity purification |
| Ig Type | Rabbit IgG |
| Formulation | Supplied as a 0.2μm filtered solution in PBS with 0.05% Proclin300, PH 7.4. |
| Storage | Store at -20℃. Avoid repeated freeze-thaw cycles. |
Human IL-2R Sandwich Immunoassay
| Recommended Concentration | Sample | ||
|---|---|---|---|
| CLIA | Capture | 1-4ug/mL | Rabbit anti-Human IL-2R mAb(Cat. No.RM17892) |
| Detection | 0.5-2ug/mL | Rabbit anti-Human IL-2R mAb(Cat. No.RM17893) | |
| Standard | 5-2000pg/mL | Recombinant Human IL-2R Protein |
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