| Product name | Rabbit anti-Human IL-2R mAb (DET） |
|---|---|
| Catalog No. | RM17897 |
| Catagory | Elisa Antibody Kit |
| Application | ELISA |
| Description | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. |
| Immunogen | Recombinant Human IL-2R alpha Protein |
| Purirty | Affinity purification |
| Ig Type | Rabbit IgG |
| Formulation | Supplied as a 0.2um filtered solution in PBS with 0.05%ProClin 300, PH 7.4. |
| CrossReactivity | No cross-reactivity in ELISA with recombinant Human IFN-γ, Human IL-1α, Human IL-1β, Human IL-1ra, Human IL-2, Human IL-3, Human IL-4, Human IL-5, Human IL-6, Human IL-8, Human IL-9, Human IL-10, Human IL-11, Human IL-12, Human IL-13, Human M-CSF, Human TGF-β1, Human TNF-α, Mouse IL-1β, Mouse IL-4, Mouse IL-5, Mouse IL-6, Mouse IL-9, Mouse IL-10, Mouse IL-13, Mouse TNF-α |
| Storage | Store at -20℃. Avoid repeated freeze-thaw cycles. |
Human IL-2R Sandwich Immunoassay
| Recommended Concentration | Sample | ||
|---|---|---|---|
| ELISA | Capture | 1-4ug/mL | Rabbit anti-Human IL-2R mAb(Cat. No.RM17896) |
| Detection | 0.01-0.04ug/mL | Rabbit anti-Human IL-2R mAb(Cat. No.RM17897) | |
| Standard | 31.25-2000pg/mL | Recombinant Human IL-2R Protein |
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