Basic Information
| Clone | Muromonab Biosimilar |
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| Molecular Weight | 150 kDa |
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| Endotoxin | <1EU/mg (<0.001EU/μg)Determined by LAL gel clotting assay |
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| Sterility | 0.2 μm filtration |
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| Aggregation | <5% Determined by SECP |
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| Purity | >95% Determined by SDS-PAGE |
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Product Information
| Production | Purified from cell culture supernatant in an animal-free facility |
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| Purification | Protein A or G purification |
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| Storage | 2 - 8°C for up to 4 weeks and -80°C for long term storage (Avoid repeated freezing and thawing) |
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Target Background
Muromonab (OKT-3) is a monoclonal anti-CD3 antibody used as immunosuppressive therapy in kidney, heart, and liver transplant patients.Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).Muromonab binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.
Immunogen Information
| Isotype | Mouse IgG2a kappa |
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| Immunogen | Human CD3 |
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| RecommendedIsotype Control(s) | In Vivo Grade Recombinant Mouse IgG2a Kappa Isotype Control Antibody |
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| Recommended Dilution Buffer | 1×PBS pH 7.0 |
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* For research use only. Not for therapeutic or diagnostic purposes.
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