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Phospho-TrkB-Y705 Rabbit pAb (AP0423)

Tested applications:WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP InhibitionReactivity:Human, Mouse

Western blot analysis of lysates from mouse brain tissue, using Phospho-TrkB-Y705 Rabbit pAb (AP0423).
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% BSA.

Overview

Product name	Phospho-TrkB-Y705 Rabbit pAb
Catalog No.	AP0423
Host species	Rabbit
Purification method	Affinity purification
Isotype	IgG

Background

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.

Immunogen information

Immunogen	A synthetic phosphorylated peptide around Y705 of human TrkB (NP_001018074.1).
Sequence	TDYYR
Gene ID
Swiss Prot
Synonyms	OBHD; TRKB; DEE58; trk-B; EIEE58; GP145-TrkB; Phospho-TrkB-Y705
Calculated MW	92kDa
Observed MW	140kDa

Applications

Reactivity	Human, Mouse
Tested applications	WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP Inhibition
Recommended dilution	WB 1:500 - 1:2000
Storage buffer	Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Key application	Western blotting
Positive samples	Mouse brain
Cellular location	Cell membrane, Endosome membrane, Single-pass type I membrane protein
Customer validation	WB(Rattus norvegicus, Mus musculus, Homo sapiens)

Research Area

Phospho-TrkB-Y705 Rabbit pAb images

Western blot - Phospho-TrkB-Y705 Rabbit pAb (AP0423)

* For research use only. Not for therapeutic or diagnostic purposes.

Product Protocols

References for Phospho-TrkB-Y705 Rabbit pAb (AP0423)

Product:

Phospho-TrkB-Y705 Rabbit pAb

Journal:

Frontiers in cellular neuroscience

Application:

IF:

6.1

Species:

Rattus norvegicus

PMID:

29773978

Title:

Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in Offspring Rats: Beneficial Effects of Maternal Exercise

References for Phospho-TrkB-Y705 Rabbit pAb (AP0423)

Product:

Phospho-TrkB-Y705 Rabbit pAb

Journal:

Pharmacology, Biochemistry, and Behavior

Application:

IF:

3.3

Species:

Mus musculus

PMID:

31866390

Title:

Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role of BDNF-TrkB signaling

References for Phospho-TrkB-Y705 Rabbit pAb (AP0423)

Product:

Phospho-TrkB-Y705 Rabbit pAb

Journal:

Mediators Inflamm

Application:

IF:

4.6

Species:

Mus musculus

PMID:

32655312

Title:

Dexmedetomidine Attenuates Neurotoxicity in Developing Rats Induced by Sevoflurane through Upregulating BDNF-TrkB-CREB and Downregulating ProBDNF-P75NRT-RhoA Signaling Pathway

References for Phospho-TrkB-Y705 Rabbit pAb (AP0423)

Product:

Phospho-TrkB-Y705 Rabbit pAb

Journal:

Neurochem Int

Application:

IF:

4.4

Species:

Mus musculus

PMID:

32650025

Title:

Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1

References for Phospho-TrkB-Y705 Rabbit pAb (AP0423)

Product:

Phospho-TrkB-Y705 Rabbit pAb

Journal:

J Neuroinflammation

Application:

IF:

9.6

Species:

Mus musculus

PMID:

34949194

Title:

RhANP attenuates endotoxin-derived cognitive dysfunction through subdiaphragmatic vagus nerve-mediated gut microbiota–brain axis

References for Phospho-TrkB-Y705 Rabbit pAb (AP0423)

Product:

Phospho-TrkB-Y705 Rabbit pAb

Journal:

Oncology reports

Application:

IF:

3.8

Species:

Homo sapiens

PMID:

31485624

Title:

Trk inhibitor GNF‑5837 suppresses the tumor growth, survival and migration of renal cell carcinoma

References for Phospho-TrkB-Y705 Rabbit pAb (AP0423)

Product:

Phospho-TrkB-Y705 Rabbit pAb

Journal:

Cell death & disease

Application:

IF:

8.1

Species:

Mus musculus

PMID:

36806050

Title:

TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis - PMC

References for Phospho-TrkB-Y705 Rabbit pAb (AP0423)

Product:

Phospho-TrkB-Y705 Rabbit pAb

Journal:

Food & function

Application:

IF:

5.1

Species:

Mus musculus

PMID:

36938927

Title:

Study on Lactiplantibacillus plantarum R6-3 from Sayram Ketteki to prevents chronic unpredictable mild stress-induced depression in mice through microbe-gut-brain …

References for Phospho-TrkB-Y705 Rabbit pAb (AP0423)

Product:

Phospho-TrkB-Y705 Rabbit pAb

Journal:

Journal of controlled release : official journal of the Controlled Release Society

Application:

IF:

10.5

Species:

Mus musculus

PMID:

36958402