Phospho-Tyk2-Y292 Rabbit pAb (AP0565)

Datasheet

Tested applications:WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP InhibitionReactivity:Human

Overview

Product name	Phospho-Tyk2-Y292 Rabbit pAb
Catalog No.	AP0565
Host species	Rabbit
Purification method	Affinity purification
Isotype	IgG

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35.

Immunogen information

Immunogen	A synthetic phosphorylated peptide around Y292 of human Tyk2 (NP_003322.3).
Sequence	PCYIR
Gene ID
Swiss Prot
Synonyms	JTK1; IMD35; Phospho-Tyk2-Y292
Calculated MW	134kDa
Observed MW	Refer to figures

Applications

Reactivity	Human
Tested applications	WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP Inhibition
Recommended dilution	WB 1:500 - 1:2000 ELISA Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Storage buffer	Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Key application	Western blotting
Positive samples
Cellular location	cytoplasm, cytoskeleton, cytosol, extracellular exosome, nucleus.