KCNA1 Rabbit pAb (A2992)

Datasheet

Tested applications:WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP InhibitionReactivity:Human, Mouse, Rat

ABclonal:Western blot - KCNA1 Rabbit pAb (A2992)

Overview

Product name	KCNA1 Rabbit pAb
Catalog No.	A2992
Host species	Rabbit
Purification method	Affinity purification
Isotype	IgG

This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).

Immunogen information

Immunogen	A synthetic peptide corresponding to a sequence within amino acids 500-600 of human KCNA1 (Q09470).
Sequence	Email for sequence
Gene ID
Swiss Prot
Synonyms	EA1; MK1; AEMK; HBK1; HUK1; MBK1; RBK1; KV1.1
Calculated MW	56kDa
Observed MW	56kDa

Applications

Reactivity	Human, Mouse, Rat
Tested applications	WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP Inhibition
Recommended dilution	WB 1:500 - 1:2000
Storage buffer	Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Key application	Western blotting
Positive samples	U-251MG
Cellular location	Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Multi-pass membrane protein, Perikaryon, axon, dendrite, presynaptic cell membrane, synapse
Customer validation	IF(Mus musculus)