제품 > 항체 > 단일클론항체(mAb)

[KO Validated] Caspase-3 Rabbit mAb (A19654)

Tested applications:WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP InhibitionReactivity:Human, Mouse

Western blot analysis of various lysates, using [KO Validated] active + pro Caspase-3 Rabbit mAb (A19654) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 3min.

Western blot analysis of lysates from Jurkat cells, using [KO Validated] active + pro Caspase-3 Rabbit mAb (A19654) at 1:1000 dilution. Jurkat cells were treated by Etoposide (25 uM) at 37℃ for 5 hours.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 90s.

Western blot analysis of lysates from L929 cells, using [KO Validated] active + pro Caspase-3 Rabbit mAb (A19654) at 1:1000 dilution. L929 cells were treated by staurosporine(1 uM) for 3 hour.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 180s.

Western blot analysis of lysates from NIH/3T3 cells using Caspase-3 Rabbit mAb (A19654) at 1:1000 dilution incubated overnight at 4℃. NIH/3T3 cells were treated by staurosporine(1 μM) for 3 hour.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 30 μg per lane.
Blocking buffer: 3 % nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 90s.

Western blot analysis of lysates from wild type (WT) and Caspase-3 knockout (KO) 293T cells using [KO Validated] Caspase-3 Rabbit mAb (A19654) at 1:1000 dilution incubated overnight at 4℃.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25 μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 10s.

Review

Overview

Product name	[KO Validated] Caspase-3 Rabbit mAb
Catalog No.	A19654
Host species	Rabbit
Purification method	Affinity purification
Isotype	IgG
CloneNo.	ARC0133

Background

The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

Immunogen information

Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 29-175 of human Caspase-3 (P42574).
Sequence	SGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETD
Gene ID
Swiss Prot
Synonyms	CPP32; SCA-1; CPP32B; -3
Calculated MW	32kDa
Observed MW	17kDa/32kDa/35kDa/17kDa/32kDa/32kDa

Applications

Reactivity	Human, Mouse
Tested applications	WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP Inhibition
Recommended dilution	WB 1:1000 - 1:2000 ELISA Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Storage buffer	Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% sodium azid, 0.05% BSA, 50% glycerol, pH7.3.
Key application	Western blotting
Positive samples	293T, Jurkat treated by Etoposide, L929 treated by staurosporine, NIH/3T3, Mouse lung, Mouse liver, NIH/3T3, 293T
Cellular location	Cytoplasm.
Customer validation	(HeLa cells) WB(Mus musculus, Homo sapiens, Sanghuangporus vaninii, Giardia duodenalis, Rattus norvegicus, Gallus gallus, Bos taurus, Mus musculus, Other) IF(Homo sapiens, Mus musculus) IP(Rattus norvegicus)

Documents

Certificate of Compliance

To download a Certificate of Compliance, please enter your Lot number below:

Lot number

Research Area

[KO Validated] Caspase-3 Rabbit mAb images

Western blot - [KO Validated] Caspase-3 Rabbit mAb (A19654)

* For research use only. Not for therapeutic or diagnostic purposes.

Submit an review for A19654

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Reviews List

Product Protocols

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Molecular and Cellular Biochemistry

Application:

IF:

3.396

Species:

Mus musculus

PMID:

32016695

Title:

Rutin protects against pirarubicin-induced cardiotoxicity by adjusting microRNA-125b-1-3p-mediated JunD signaling pathway

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Microb Pathog

Application:

IF:

3.738

Species:

Homo sapiens

PMID:

32525021

Title:

Giardia duodenalis induces extrinsic pathway of apoptosis in intestinal epithelial cells through activation of TNFR1 and K63 de-ubiquitination of RIP1 in vitro

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Int J Biol Macromol

Application:

IF:

6.953

Species:

Sanghuangporus vaninii

PMID:

32629056

Title:

Characterization of a polysaccharide from Sanghuangporus vaninii and its antitumor regulation via activation of the p53 signaling pathway in breast cancer MCF-7 …

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Pathogens

Application:

IF:

3.492

Species:

Giardia duodenalis

PMID:

32842537

Title:

Giardia duodenalis Induces Apoptosis in Intestinal Epithelial Cells via Reactive Oxygen Species-Mediated Mitochondrial Pathway In Vitro

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Frontiers in Oncology

Application:

IF:

6.244

Species:

Homo sapiens

PMID:

32211324

Title:

LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Mol Med Rep

Application:

IF:

2.952

Species:

Homo sapiens

PMID:

33325535

Title:

Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Biol Res

Application:

IF:

5.612

Species:

Rattus norvegicus

PMID:

32928312

Title:

Palmatine ameliorates high fat diet induced impaired glucose tolerance

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Cancers (Basel)

Application:

IF:

6.639

Species:

Homo sapiens

PMID:

33546453

Title:

The Oxygen-Generating Calcium Peroxide-Modified Magnetic Nanoparticles Attenuate Hypoxia-Induced Chemoresistance in Triple-Negative Breast Cancer

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

BMC Cancer

Application:

IF:

4.43

Species:

Homo sapiens

PMID:

33557774

Title:

LncRNA MT1JP plays a protective role in intrahepatic cholangiocarcinoma by regulating miR-18a-5p/FBP1 axis

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Biochem Pharmacol

Application:

IF:

5.85

Species:

Mus musculus

PMID:

33819469

Title:

The multitargeted kinase inhibitor KW-2449 ameliorates cisplatin-induced nephrotoxicity by targeting RIPK1-mediated necroptosis

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Acta Biochim Biophys Sin (Shanghai)

Application:

IF:

3.848

Species:

Homo sapiens

PMID:

34718369

Title:

PAQR4 promotes the development of hepatocellular carcinoma by activating PI3K/AKT pathway

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Eur J Pharmacol

Application:

IF:

4.432

Species:

Rattus norvegicus

PMID:

34280397

Title:

Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4 0

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Neoplasia

Application:

IF:

5.715

Species:

Homo sapiens

PMID:

34325342

Title:

PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Can J Physiol Pharmacol

Application:

IF:

2.273

Species:

Rattus norvegicus

PMID:

34310896

Title:

The S1PR1 Agonist SEW2871 promotes the Survival of Skin Flap

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

EMBO Rep

Application:

IF:

8.807

Species:

Mus musculus

PMID:

34693625

Title:

Bclaf1 regulates c‐FLIP expression and protects cells from TNF‐induced apoptosis and tissue injury

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Cancer Biol Med

Application:

IF:

4.24

Species:

Mus musculus

PMID:

33710817

Title:

Synergistic effects of AAGL and anti-PD-1 on hepatocellular carcinoma through lymphocyte recruitment to the liver

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Int J Mol Sci

Application:

IF:

5.923

Species:

Mus musculus

PMID:

34769258

Title:

Cathepsin B Regulates Mice Granulosa Cells' Apoptosis and Proliferation In Vitro

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Autophagy

Application:

IF:

13.39

Species:

Homo sapiens

PMID:

36037300

Title:

Genome-Scale CRISPR Screen Identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

The Journal of pharmacology and experimental therapeutics

Application:

IF:

4.4

Species:

Mus musculus

PMID:

36041883

Title:

Protective Effect of Anwulignan on Gastric Injury Induced by Indomethacin in Mice

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Frontiers in immunology

Application:

IF:

8.78

Species:

Gallus gallus

PMID:

35833119

Title:

Lnc90386 Sponges miR-33-5p to Mediate Mycoplasma gallisepticum-Induced Inflammation and Apoptosis in Chickens via the JNK Pathway - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Journal of virology

Application:

IF:

6.54

Species:

Bos taurus

PMID:

35993735

Title:

Downregulation of the Long Noncoding RNA IALNCR Targeting MAPK8/JNK1 Promotes Apoptosis and Antagonizes Bovine Viral Diarrhea Virus Replication in Host …

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Application:

IF:

7.41

Species:

Homo sapiens

PMID:

36007272

Title:

Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

The Journal of pharmacology and experimental therapeutics

Application:

IF:

4.4

Species:

Rattus norvegicus

PMID:

34131018

Title:

Anwulignan Ameliorates the Intestinal Ischemia/Reperfusion

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Oxidative medicine and cellular longevity

Application:

IF:

7.31

Species:

Rattus norvegicus

PMID:

36267811

Title:

Activation of PTEN/P13K/AKT Signaling Pathway by miRNA-124-3p-Loaded Nanoparticles to Regulate Oxidative Stress Attenuates Cardiomyocyte Regulation and Myocardial Injury - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Microbial pathogenesis

Application:

IF:

3.84

Species:

Homo sapiens

PMID:

35753598

Title:

Class Ⅰ histone deacetylase inhibitor regulate of Mycobacteria–Driven guanylate-binding protein 1 gene expression

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Evidence-based complementary and alternative medicine : eCAM

Application:

IF:

2.65

Species:

Rattus norvegicus

PMID:

35899226

Title:

miR-214-3p Protects and Restores the Myocardial Tissue of Rat Myocardial Infarction Model by Targeting PTEN - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Cellular signalling

Application:

IF:

4.85

Species:

Mus musculus

PMID:

35811055

Title:

SIRT1 ameliorated septic associated-lung injury and macrophages apoptosis via inhibiting endoplasmic reticulum stress

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Molecular neurobiology

Application:

IF:

5.68

Species:

Homo sapiens

PMID:

36053436

Title:

Isobavachalcone's Alleviation of Pyroptosis Contributes to Enhanced Apoptosis in Glioblastoma: Possible Involvement of NLRP3

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Evidence-based complementary and alternative medicine : eCAM

Application:

IF:

2.65

Species:

Mus musculus

PMID:

35747379

Title:

Renal Protective Mechanisms of Shenyuan Particle in Db/Db Mice: A Study Based on Network Pharmacology - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Journal of cellular and molecular medicine

Application:

IF:

5.29

Species:

Mus musculus

PMID:

36111515

Title:

CaMKII orchestrates endoplasmic reticulum stress and apoptosis in doxorubicin‐induced cardiotoxicity by regulating the IRE1α/XBP1s pathway

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Molecular and cellular endocrinology

Application:

IF:

4.36

Species:

Homo sapiens

PMID:

35429597

Title:

Elevated latent transforming growth factor beta binding protein 2 in endometriosis promotes endometrial stromal cell invasion and proliferation via the NF-kB signaling pathway

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Italian journal of pediatrics

Application:

IF:

3.28

Species:

Homo sapiens

PMID:

36600293

Title:

SIGIRR-caspase-8 signaling mediates endothelial apoptosis in Kawasaki disease - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Drug development research

Application:

IF:

Species:

Homo sapiens

PMID:

36598070

Title:

Thrombospondin‐1 mimic peptide PKHB1 induced endoplasmic reticulum stress‐mediated but CD47‐independent apoptosis in non‐small cell lung cancer

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Veterinary research

Application:

IF:

3.82

Species:

Gallus gallus

PMID:

36471418

Title:

Mycoplasma gallisepticum escapes the host immune response via gga-miR-365-3p/SOCS5/STATs axis - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Journal of atherosclerosis and thrombosis

Application:

IF:

4.39

Species:

Mus musculus

PMID:

36436875

Title:

High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

International journal of molecular sciences

Application:

IF:

6.2

Species:

Homo sapiens

PMID:

36430694

Title:

Mallotucin D, a Clerodane Diterpenoid from Croton crassifolius, Suppresses HepG2 Cell Growth via Inducing Autophagic Cell Death and Pyroptosis - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

eLife

Application:

IF:

8.71

Species:

Mus musculus

PMID:

35972780

Title:

Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Frontiers in pharmacology

Application:

IF:

5.98

Species:

Mus musculus

PMID:

36467049

Title:

Exploring the potential mechanism of Fritiliariae Irrhosae Bulbus on ischemic stroke based on network pharmacology and experimental validation - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Frontiers in immunology

Application:

IF:

8.78

Species:

Mus musculus

PMID:

36713420

Title:

CTSB promotes sepsis-induced acute kidney injury through activating mitochondrial apoptosis pathway - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Acta pharmacologica Sinica

Application:

IF:

7.16

Species:

Rattus norvegicus

PMID:

36807413

Title:

Downregulation of NUP93 aggravates hypoxia-induced death of cardiomyocytes in vitro through abnormal regulation of gene transcription

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Bioactive materials

Application:

IF:

16.87

Species:

Rattus norvegicus

PMID:

37122901

Title:

Cardiac patches made of brown adipose-derived stem cell sheets and conductive electrospun nanofibers restore infarcted heart for ischemic myocardial infarction - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

International immunopharmacology

Application:

IF:

5.71

Species:

Mus musculus

PMID:

37071966

Title:

Twist1 Rescue Calcium Overload And Apoptosis Induced by Inflammatory Microenvironment in S. Aureus-Induced Osteomyelitis

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

International journal of biological sciences

Application:

IF:

10.75

Species:

Mus musculus

PMID:

37781508

Title:

Tofacitinib Promotes Functional Recovery after Spinal Cord Injury by Regulating Microglial Polarization via JAK/STAT Signaling Pathway - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Molecular medicine (Cambridge, Mass.)

Application:

IF:

6.37

Species:

Homo sapiens

PMID:

37626284

Title:

Elevated galectin-3 levels detected in women with hyperglycemia during early and mid-pregnancy antagonizes high glucose-induced trophoblast cells apoptosis via galectin-3/foxc1 pathway - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Translational neurodegeneration

Application:

IF:

9.88

Species:

Homo sapiens

PMID:

37620916

Title:

-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

The Journal of toxicological sciences

Application:

IF:

1.79

Species:

Homo sapiens

PMID:

37532580

Title:

The protective effect of thiolutin on doxorubicin-induced H9c2 cardiomyocyte injury

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Molecular medicine reports

Application:

IF:

3.42

Species:

Rattus norvegicus

PMID:

37711057

Title:

Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Current issues in molecular biology

Application:

IF:

2.97

Species:

Mus musculus

PMID:

37998720

Title:

Implications of Activating the ANT2/mTOR/PGC-1 Feedback Loop: Insights into Mitochondria-Mediated Injury in Hypoxic Myocardial Cells - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Application:

IF:

7.41

Species:

Homo sapiens

PMID:

37385210

Title:

Synthesis and in-vitro study of a novel ligustrazine diselenide as a potential chemotherapy drug for lung adenocarcinoma

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Journal of cardiovascular translational research

Application:

IF:

3.21

Species:

Mus musculus

PMID:

37784003

Title:

Danlou Tablet Protects Against Myocardial Infarction Through Promoting eNOS-Dependent Endothelial Protection and Angiogenesis

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Nature

Application:

IF:

69.5

Species:

Mus musculus

PMID:

37794190

Title:

An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

International journal of antimicrobial agents

Application:

IF:

15.44

Species:

Mus musculus

PMID:

37666435

Title:

The protective effects of benzaldehyde combined with albendazole against brain injury induced by Angiostrongylus cantonensis infection in mice.

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Biological & pharmaceutical bulletin

Application:

IF:

2.26

Species:

Homo sapiens

PMID:

36724950

Title:

GLIS Family Zinc Finger 3 Promotes Triple-Negative Breast Cancer Progression by Inducing Cell Proliferation, Migration and Invasion, and Activating the NF

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Drug development research

Application:

IF:

Species:

Homo sapiens

PMID:

36852868

Title:

Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Photodiagnosis and photodynamic therapy

Application:

IF:

3.57

Species:

Homo sapiens

PMID:

37989473

Title:

Indocyanine Green Based Photodynamic Therapy for Keloids: Fundamental Investigation and Clinical Improvement

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Application:

IF:

5.57

Species:

Homo sapiens

PMID:

38128689

Title:

Autophagy mediated FTH1 degradation activates gasdermin E dependent pyroptosis contributing to diquat induced kidney injury

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

International journal of molecular sciences

Application:

IF:

6.2

Species:

Homo sapiens

PMID:

35887373

Title:

Targeted Co-Delivery of Gefitinib and Rapamycin by Aptamer-Modified Nanoparticles Overcomes EGFR-TKI Resistance in NSCLC via Promoting Autophagy - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

International journal of molecular sciences

Application:

IF:

6.2

Species:

Homo sapiens

PMID:

35887373

Title:

Targeted Co-Delivery of Gefitinib and Rapamycin by Aptamer-Modified Nanoparticles Overcomes EGFR-TKI Resistance in NSCLC via Promoting Autophagy - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Drug design, development and therapy

Application:

WB, IF

IF:

4.31

Species:

Homo sapiens, Mus musculus

PMID:

37020802

Title:

5-Fluorouracil Combined with Rutaecarpine Synergistically Suppresses the Growth of Colon Cancer Cells by Inhibiting STAT3 - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Journal of cellular and molecular medicine

Application:

IF:

5.29

Species:

Homo sapiens

PMID:

37859585

Title:

Brusatol enhances MEF2A expression to inhibit RCC progression through the Wnt signalling pathway in renal cell carcinoma

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Chinese medicine

Application:

IF:

4.54

Species:

Mus musculus

PMID:

38360696

Title:

Paclitaxel combined with Compound K inducing pyroptosis of non-small cell lung cancer cells by regulating Treg/Th17 balance - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Research (Washington, D.C.)

Application:

IF:

Species:

Rattus norvegicus

PMID:

38410280

Title:

Exercise-Induced miR-210 Promotes Cardiomyocyte Proliferation and Survival and Mediates Exercise-Induced Cardiac Protection against Ischemia/Reperfusion Injury - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

International journal of biological macromolecules

Application:

IF:

8.2

Species:

Homo sapiens

PMID:

38401583

Title:

Deficiency of polypeptide N-acetylgalactosamine transferase 9 contributes to a risk for Parkinson's disease via mitochondrial dysfunctions

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Molecules (Basel, Switzerland)

Application:

IF:

4.6

Species:

Homo sapiens

PMID:

38398624

Title:

Teadenol B as a Component of Microorganism-Fermented Tea Extract Inhibited Breast Cancers by Promoting Autophagy - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Biochemical pharmacology

Application:

IF:

5.8

Species:

Homo sapiens

PMID:

38458329

Title:

SRT1720 inhibits bladder cancer cell progression by impairing autophagic flux

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

International journal of biological sciences

Application:

IF:

9.2

Species:

Mus musculus

PMID:

38481816

Title:

ALKBH5 facilitates the progression of skin cutaneous melanoma via mediating ABCA1 demethylation and modulating autophagy in an m6A-dependent

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

The Science of the total environment

Application:

IF:

9.8

Species:

Homo sapiens

PMID:

38061639

Title:

Inhalation of ammonia promotes apoptosis and induces autophagy in hepatocytes via Bax/BCl-2 and m-TOR/ATG5/LC-3bII axes

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Life Sci

Application:

IF:

6.78

Species:

Rattus norvegicus

PMID:

33774032

Title:

Astragaloside IV-targeting miRNA-1 attenuates lipopolysaccharide-induced cardiac dysfunction in rats through inhibition of apoptosis and autophagy

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Chinese herbal medicines

Application:

IF:

Species:

Rattus norvegicus

PMID:

36875432

Title:

Protective effect of hydroxysafflor yellow A on MSCs against senescence induced by D-galactose

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Front Pharmacol

Application:

IF:

5.988

Species:

Mus musculus

PMID:

34867383

Title:

Network Pharmacology and Molecular Docking-Based Investigation: Prunus mume Against Colorectal Cancer via Silencing RelA Expression

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Redox biology

Application:

IF:

10.787

Species:

Mus musculus

PMID:

35144051

Title:

Selenoprotein K protects skeletal muscle from damage and is required for satellite cells-mediated myogenic differentiation

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Journal of biochemistry

Application:

IF:

3.24

Species:

Rattus norvegicus

PMID:

33837411

Title:

MiR-20a-5p overexpression prevented diabetic cardiomyopathy via inhibition of cardiomyocyte apoptosis, hypertrophy, fibrosis and JNK/NF-B signalling pathway

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Journal of medicinal chemistry

Application:

IF:

8.03

Species:

Mus musculus

PMID:

35852796

Title:

Development of Strigolactones as Novel Autophagy/Mitophagy Inhibitors against Colorectal Cancer Cells by Blocking the AutophagosomeLysosome Fusion

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

International immunopharmacology

Application:

WB, IP

IF:

5.71

Species:

Rattus norvegicus

PMID:

35753124

Title:

Platelet-rich plasma-derived exosomes attenuate intervertebral disc degeneration by promoting NLRP3 autophagic degradation in macrophages

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

International immunopharmacology

Application:

IF:

5.71

Species:

Rattus norvegicus

PMID:

36461588

Title:

Hypoxic mesenchymal stem cell-derived exosomes alleviate ulcerative colitis injury by limiting intestinal epithelial cells reactive oxygen species accumulation and

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

The Science of the total environment

Application:

IF:

10.75

Species:

Homo sapiens

PMID:

37709070

Title:

Effects of triclosan exposure on stem cells from human exfoliated deciduous teeth (SHED) fate

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

British journal of pharmacology

Application:

IF:

7.3

Species:

Mus musculus

PMID:

38555910

Title:

Identification of a marinederived sesquiterpenoid, Compound8, that inhibits tumour necrosis factorinduced cell death by blocking complex II assembly

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Discover oncology

Application:

IF:

2.2

Species:

Mus musculus

PMID:

38809316

Title:

Shenqi Fuzheng injection hinders non-small cell lung cancer cell growth by regulating the Bax/Bcl-2 signaling pathway - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Aging

Application:

IF:

5.2

Species:

Homo sapiens

PMID:

38809514

Title:

Bufotalin enhances apoptosis and TMZ chemosensitivity of glioblastoma cells by promoting mitochondrial dysfunction via AKT signaling pathway - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Experimental cell research

Application:

IF:

3.7

Species:

Homo sapiens

PMID:

38796135

Title:

Exosomal LRG1 promotes non-small cell lung cancer proliferation and metastasis by binding FN1 protein

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Clinical, cosmetic and investigational dermatology

Application:

IF:

2.3

Species:

Homo sapiens

PMID:

38911338

Title:

Integrated Analysis Reveals COL4A3 as a Novel Diagnostic and Therapeutic Target in UV-Related Skin Cutaneous Melanoma - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Heliyon

Application:

IF:

Species:

Other

PMID:

38933967

Title:

Ginsenoside Rd reduces cell proliferation of non-small cell lung cancer cells by p53-mitochondrial apoptotic pathway - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

ACS pharmacology & translational science

Application:

IF:

Species:

Mus musculus

PMID:

39022361

Title:

Bone Morphogenetic Protein Signaling Agonist SB4 (BMPSB4) Inhibits Corticotroph Pituitary Neuroendocrine Tumors by Activation of Autophagy via a BMP4/SMADs

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Bioorganic chemistry

Application:

IF:

5.1

Species:

Other

PMID:

38772289

Title:

Design, synthesis, biological evaluation of novel piperidine-based derivatives as potent poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Phytomedicine

Application:

IF:

7.9

Species:

Other

PMID:

34781232

Title:

Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity through the AKT/Bcl-2 signaling pathway

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Frontiers in Pharmacology

Application:

IF:

5.6

Species:

Mus musculus

PMID:

38562460

Title:

Isoquercitrin alleviates pirarubicin-induced cardiotoxicity in vivo and in vitro by inhibiting apoptosis through Phlpp1/AKT/Bcl-2 signaling pathway - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Application:

IF:

15.1

Species:

Mus musculus

PMID:

39189475

Title:

mRNA-Lipid Nanoparticle-Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple-Negative Breast Cancer - PMC

References for [KO Validated] Caspase-3 Rabbit mAb (A19654)

Product:

[KO Validated] Caspase-3 Rabbit mAb

Journal:

Artificial cells, nanomedicine, and biotechnology

Application:

IF:

5.8

Species:

Homo sapiens

PMID:

31219352