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β-Amyloid(1-40) Rabbit mAb (A24949)

Datasheet

Tested applications:WBIHC-PIF/ICCIPChIPChIP-seqRIPFCFC(Intra)ELISAMeDIPNucleotide ArrayDBFACSCoIPCUT&TagmeRIPInhibitionReactivity:Mouse

ABclonal: - β-Amyloid(1-40) Rabbit mAb (A24949)

Dot-blot analysis of β-Amyloid 1-40 and β-Amyloid 1-42 proteins using β-Amyloid(1-40) Rabbit mAb (A24949) at 1:1000 dilution.

ABclonal:Immunohistochemistry - β-Amyloid(1-40) Rabbit mAb (A24949)

Immunohistochemistry analysis of paraffin-embedded 5XFAD Mouse brain tissue (model for Alzheimer disease, Left) and Mouse brain tissue (normal, Right) using β-Amyloid(1-40) Rabbit mAb (A24949) at a dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.

ABclonal:Immunofluorescence - β-Amyloid(1-40) Rabbit mAb (A24949)

Confocal imaging of paraffin-embedded 5XFAD mouse brain (model for Alzheimer disease, left) and BALB/c mouse brain(normal, right) using β-Amyloid(1-40) Rabbit mAb (A24949, dilution 1:200) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007, dilution 1:500) (Red). DAPI was used for nuclear staining (Blue). Objective: 40x.

Overview

Product nameβ-Amyloid(1-40) Rabbit mAb
Catalog No.A24949
Host speciesRabbit
Purification methodAffinity purification
IsotypeIgG
CloneNo.ARC65337
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 671-770 of human β-Amyloid(1-40)(NP_000475.1).
SequenceMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Gene ID
Swiss Prot
SynonymsAAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma; alpha-sAPP; β-Amyloid(1-40)
Calculated MW87kDa
Observed MW
ReactivityMouse
Tested applicationsWBIHC-PIF/ICCIPChIPChIP-seqRIPFCFC(Intra)ELISAMeDIPNucleotide ArrayDBFACSCoIPCUT&TagmeRIPInhibition
Recommended dilution
  • DB 1:500 - 1:1000
  • IHC-P 1:200 - 1:800
  • IF/ICC 1:200 - 1:800
  • ELISA Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Storage bufferStore at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Key applicationImmunohistochemistry    Immunofluorescence    
Positive samples
Cellular locationMembrane, Single-pass type I membrane protein, clathrin-coated pit.

Documents

Certificate of Compliance

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Lot number

ABclonal: - β-Amyloid(1-40) Rabbit mAb (A24949)}

- β-Amyloid(1-40) Rabbit mAb (A24949)

Dot-blot analysis of β-Amyloid 1-40 and β-Amyloid 1-42 proteins using β-Amyloid(1-40) Rabbit mAb (A24949) at 1:1000 dilution.
ABclonal:Immunohistochemistry - β-Amyloid(1-40) Rabbit mAb (A24949)}

Immunohistochemistry - β-Amyloid(1-40) Rabbit mAb (A24949)

Immunohistochemistry analysis of paraffin-embedded 5XFAD Mouse brain tissue (model for Alzheimer disease, Left) and Mouse brain tissue (normal, Right) using β-Amyloid(1-40) Rabbit mAb (A24949) at a dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.
ABclonal:Immunofluorescence - β-Amyloid(1-40) Rabbit mAb (A24949)}

Immunofluorescence - β-Amyloid(1-40) Rabbit mAb (A24949)

Confocal imaging of paraffin-embedded 5XFAD mouse brain (model for Alzheimer disease, left) and BALB/c mouse brain(normal, right) using β-Amyloid(1-40) Rabbit mAb (A24949, dilution 1:200) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007, dilution 1:500) (Red). DAPI was used for nuclear staining (Blue). Objective: 40x.

* For research use only. Not for therapeutic or diagnostic purposes.

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