제품 > 항체 > 다중클론항체(pAb)

[KO Validated] p53 Rabbit pAb (A0263)

Tested applications:WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP InhibitionReactivity:Human, Mouse, Rat

Western blot analysis of lysates from MCF7 cells using p53 Rabbit pAb (A0263) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25 μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 30s.

Western blot analysis of lysates from wild type (WT) and p53 knockout (KO) 293T cells using p53 Rabbit pAb (A0263) at 1:1000 dilution incubated overnight at 4℃.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25 μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 10s.

ABclonal:Immunohistochemistry - [KO Validated] p53 Rabbit pAb (A0263)

Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma using p53 Rabbit pAb (A0263) at dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.

ABclonal:Immunoprecipitation - [KO Validated] p53 Rabbit pAb (A0263)

Immunoprecipitation of p53 in 200 µg extracts from 293T cells using 3 µg p53 Rabbit pAb (A0263). Western blot analysis was performed using p53 Rabbit pAb (A0263) at 1:3000 dilution.

Review

Overview

Product name	[KO Validated] p53 Rabbit pAb
Catalog No.	A0263
Host species	Rabbit
Purification method	Affinity purification
Isotype	IgG

Background

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Immunogen information

Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-393 of human p53 (NP_000537.3).
Sequence	MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Gene ID
Swiss Prot
Synonyms	P53; BCC7; LFS1; BMFS5; TRP53; p53
Calculated MW	44kDa
Observed MW	53kDa//53kDa/53kDa

Applications

Reactivity	Human, Mouse, Rat
Tested applications	WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra)ELISA MeDIP Nucleotide Array DB FACS CoIP CUT&Tag meRIP Inhibition
Recommended dilution	WB 1:500 - 1:2000 IHC-P 1:50 - 1:200 IF/ICC 1:50 - 1:200 IP 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells ELISA Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Storage buffer	Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Key application	Western blotting Immunohistochemistry Immunofluorescence Immunoprecipitation
Positive samples	293T, MCF7, 293T, 293T
Cellular location	Cytoplasm, Endoplasmic reticulum, Mitochondrion matrix, Nucleus, PML body.
Customer validation	(Human cells, SW480) WB(Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Megalobrama amblycephala, Sus scrofa, Mus musculus, Danio rerio) IHC(Mus musculus, Homo sapiens, Canis familiaris, Rattus norvegicus) IF(Rattus norvegicus, Mus musculus, Homo sapiens) ChIP(Homo sapiens) IP(Mus musculus, Homo sapiens) IF(Homo sapiens, Rattus norvegicus) IHC(Rattus norvegicus) WB(Homo sapiens, Mus musculus)

Documents

Certificate of Compliance

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Lot number

Research Area

[KO Validated] p53 Rabbit pAb images

Western blot - [KO Validated] p53 Rabbit pAb (A0263)

Immunohistochemistry - [KO Validated] p53 Rabbit pAb (A0263)

Immunoprecipitation - [KO Validated] p53 Rabbit pAb (A0263)

Immunoprecipitation of p53 in 200 µg extracts from 293T cells using 3 µg p53 Rabbit pAb (A0263). Western blot analysis was performed using p53 Rabbit pAb (A0263) at 1:3000 dilution.

* For research use only. Not for therapeutic or diagnostic purposes.

Submit an review for A0263

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Reviews List

Product Protocols

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

International Journal Of Clinical and Experimental Pathology

Application:

IF:

0.279

Species:

Homo sapiens

PMID:

24427328

Title:

KAT5 silencing induces apoptosis of GBC-SD cells through p38MAPK-mediated upregulation of cleaved Casp9

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

International Journal Of Clinical and Experimental Pathology

Application:

IF:

0.279

Species:

Homo sapiens

PMID:

24133586

Title:

Systematic screen with kinases inhibitors reveals kinases play distinct roles in growth of osteoprogenitor cells

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

American Journal Of Translational Research

Application:

IF:

4.06

Species:

Homo sapiens

PMID:

23634246

Title:

AURKA suppression induces DU145 apoptosis and sensitizes DU145 to docetaxel treatment

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

International journal of biological sciences

Application:

IF:

6.58

Species:

Mus musculus

PMID:

30745821

Title:

NFAT5 is Regulated by p53/miR-27a Signal Axis and Promotes Mouse Ovarian Granulosa Cells Proliferation.

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

American journal of translational research

Application:

IF:

4.06

Species:

Rattus norvegicus

PMID:

31217873

Title:

Effect of astaxanthin on apoptosis of rat renal tubular epithelial cells induced by iohexol.

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Aging

Application:

IF:

5.682

Species:

Homo sapiens

PMID:

32096479

Title:

Adipose-derived mesenchymal stem cells-derived exosome-mediated microRNA-342-5p protects endothelial cells against atherosclerosis

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

BMC Chemistry

Application:

IF:

2.61

Species:

Homo sapiens

PMID:

32099972

Title:

Finding an efficient tetramethylated hydroxydiethylene of resveratrol analogue for potential anticancer agent

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

American Journal of Translational Research

Application:

IF:

4.06

Species:

Homo sapiens

PMID:

31814908

Title:

A pilot study comparing the genetic molecular biology of gestational and non-gestational choriocarcinoma

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Digestive Diseases and Sciences

Application:

IF:

3.199

Species:

Homo sapiens

PMID:

32347436

Title:

Upregulation of Excision Repair Cross-Complementation Group 6-Like (ERCC6L) Promotes Tumor Growth in Hepatocellular Carcinoma

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Toxins

Application:

IF:

4.546

Species:

Gallus gallus

PMID:

30857375

Title:

Proanthocyanidins Alleviates AflatoxinB1-Induced Oxidative Stress and Apoptosis through Mitochondrial Pathway in the Bursa of Fabricius of Broilers.

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Frontiers in Immunology

Application:

IF:

7.561

Species:

Homo sapiens

PMID:

31281315

Title:

The Molecular Evolution and Functional Divergence of Lamprey Programmed Cell Death Genes.

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Frontiers in Cellular Neuroscience

Application:

IF:

5.505

Species:

Mus musculus

PMID:

31920551

Title:

Inhibition of DRP-1-Dependent Mitophagy Promotes Cochlea Hair Cell Senescence and Exacerbates Age-Related Hearing Loss.

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Cancer Immunol Immunother

Application:

IHC

IF:

6.968

Species:

Mus musculus

PMID:

32607768

Title:

Induction of systemic immune responses and reversion of immunosuppression in the tumor microenvironment by a therapeutic vaccine for cervical cancer

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Bioengineered

Application:

IF:

3.269

Species:

Homo sapiens

PMID:

32842855

Title:

Upregulation of Oxidative stress-responsive 1 (OXSR1) Predicts Poor Prognosis and Promotes Hepatocellular Carcinoma Progression

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Genes

Application:

IF:

4.096

Species:

Homo sapiens

PMID:

33158173

Title:

Lymphatic Metastasis of NSCLC Involves Chemotaxis Effects of Lymphatic Endothelial Cells through the CCR7–CCL21 Axis Modulated by TNF-α

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Genes (Basel)

Application:

IF:

4.096

Species:

Homo sapiens

PMID:

33371207

Title:

Transcriptional Regulation of CD40 Expression by 4 Ribosomal Proteins via a Functional SNP on a Disease-Associated CD40 Locus

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Front Immunol

Application:

IF:

7.561

Species:

Homo sapiens

PMID:

33381110

Title:

Systems Immunology Analysis Reveals an Immunomodulatory Effect of Snail-p53 Binding on Neutrophil- and T Cell-Mediated Immunity in KRAS Mutant Non-Small Cell Lung Cancer

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Toxicol Res (Camb)

Application:

IF:

3.52

Species:

Rattus norvegicus

PMID:

34733482

Title:

Long-term repetitive exposure to excess iodine induces mitochondrial apoptosis, and alters monoamine neurotransmitters in hippocampus of rats of different genders

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Antioxidants (Basel)

Application:

IF:

6.31

Species:

Megalobrama amblycephala

PMID:

34572975

Title:

High-Carbohydrate Diet Alleviates the Oxidative Stress, Inflammation and Apoptosis of Megalobrama amblycephala Following Dietary Exposure to Silver Nanoparticles

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Cancer Manag Res

Application:

IHC

IF:

3.989

Species:

Mus musculus

PMID:

34285577

Title:

Inhibition of Orthotopic Genital Cancer Induced by Subcutaneous Administration of Human Papillomavirus Peptide Vaccine with CpG Oligodeoxynucleotides as an Adjuvant in Mice

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Aging (Albany NY)

Application:

IF:

5.682

Species:

Homo sapiens

PMID:

34559682

Title:

SUV39H2/KMT1B Inhibits the cardiomyocyte senescence phenotype by down-regulating BTG2/PC3

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Bioorg Chem

Application:

IF:

5.275

Species:

Homo sapiens

PMID:

34954572

Title:

Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

The international journal of biochemistry & cell biology

Application:

IF:

5.08

Species:

Sus scrofa

PMID:

24333671

Title:

Transcription factor C/EBPβ and 17β-estradiol promote transcription of the porcine p53 gene

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Application:

IF:

17.52

Species:

Mus musculus

PMID:

36057999

Title:

Engineering Alendronate-Composed Iron Nanochelator for Efficient Peritoneal Carcinomatosis Treatment - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Biomedical journal

Application:

IF:

7.89

Species:

Mus musculus

PMID:

35300947

Title:

3-Hydroxybenzaldehyde and 4-Hydroxybenzaldehyde enhance survival of mouse astrocytes treated with Angiostrongylus cantonensis young adults excretory …

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Biochimica et biophysica acta. Molecular and cell biology of lipids

Application:

IF:

5.22

Species:

Homo sapiens

PMID:

36690321

Title:

Zeaxanthin prevents ferroptosis by promoting mitochondrial function and inhibiting the p53 pathway in free fatty acid-induced HepG2 cells

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Frontiers in endocrinology

Application:

IF:

6.05

Species:

Rattus norvegicus

PMID:

36761198

Title:

Cisplatin causes erectile dysfunction by decreasing endothelial and smooth muscle content and inducing cavernosal nerve senescence in rats - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Nature communications

Application:

IF:

17.69

Species:

Mus musculus

PMID:

36797299

Title:

Nicotine rebalances NAD+ homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Neuroendocrinology

Application:

IF:

5.13

Species:

Mus musculus

PMID:

36758529

Title:

5-Iodotubercidin Inhibits the Growth of Insulinoma Cells by Inducing Apoptosis

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Annals of translational medicine

Application:

IF:

3.61

Species:

Homo sapiens

PMID:

36923082

Title:

E2F1 inhibits cellular senescence and promotes oxaliplatin resistance in colorectal cancer - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Translational oncology

Application:

IF:

4.8

Species:

Mus musculus

PMID:

36966611

Title:

GD2 CAR-T cells in combination with Nivolumab exhibit enhanced antitumor efficacy - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Journal of orthopaedic surgery and research

Application:

IF:

2.67

Species:

Homo sapiens

PMID:

36944987

Title:

Mechanism of YAP1 in the senescence and degeneration of endplate chondrocytes induced by intermittent cyclic mechanical tension - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Archives of biochemistry and biophysics

Application:

IF:

4.11

Species:

Homo sapiens

PMID:

37142078

Title:

Mechanisms of hedgehog, calcium and retinoic acid signalling pathway inhibitors: Plausible modes of action along the MLL–EZH2-p53 axis in cellular growth control

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

Application:

IF:

10.27

Species:

Mus musculus

PMID:

37147244

Title:

The therapeutic effect of Tanshinone IIA in mouse astrocytes after treatment with Angiostrongylus cantonensis fifth-stage larval excretory-secretory products

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Application:

IHC

IF:

7.41

Species:

Mus musculus

PMID:

36942597

Title:

Potential cardioprotective effects of Amentoflavone in doxorubicin-induced cardiotoxicity in mice

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Environmental toxicology

Application:

IF:

4.1

Species:

Mus musculus

PMID:

37421283

Title:

MiR4943p aggravates pirarubicininduced cardiomyocyte injury by regulating MDM4/p53 signaling pathway

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

International journal of antimicrobial agents

Application:

IF:

15.44

Species:

Mus musculus

PMID:

37666435

Title:

The protective effects of benzaldehyde combined with albendazole against brain injury induced by Angiostrongylus cantonensis infection in mice.

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Plos One

Application:

IF:

3.752

Species:

Homo sapiens, Mus musculus

PMID:

23940708

Title:

Comparison of toxicity of benzene metabolite hydroquinone in hematopoietic stem cells derived from murine embryonic yolk sac and adult bone marrow

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Cell Death Discov

Application:

IF:

7.109

Species:

Homo sapiens, Mus musculus

PMID:

34759267

Title:

Small nucleolar RNA 42 promotes the growth of hepatocellular carcinoma through the p53 signaling pathway

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Acta Pharmacol Sin

Application:

IF:

7.169

Species:

Danio rerio

PMID:

32796956

Title:

Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Clinical and translational medicine

Application:

IF:

8.55

Species:

Homo sapiens, Mus musculus

PMID:

35872650

Title:

Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Molecules (Basel, Switzerland)

Application:

IF:

4.92

Species:

Homo sapiens

PMID:

35744840

Title:

Dihydrotanshinone I Enhances Cell Adhesion and Inhibits Cell Migration in Osteosarcoma U-2 OS Cells through CD44 and Chemokine Signaling - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

iScience

Application:

WB, ChIP

IF:

6.1

Species:

Homo sapiens

PMID:

36843839

Title:

Telomeres cooperate in zygotic genome activation by affecting DUX4/Dux transcription - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Ecotoxicology and environmental safety

Application:

IF:

7.12

Species:

Homo sapiens

PMID:

38134636

Title:

MDM2-p53 mediate a miR-181c-3p/LIF axis to regulate low dose-rate radiation-induced DNA damage in human B lymphocytes

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Advanced healthcare materials

Application:

IF:

11.09

Species:

Homo sapiens,Rattus norvegicus

PMID:

37949452

Title:

Wireless Electric Cues Mediate Autologous DPSCLoaded Conductive Hydrogel Microspheres to Engineer The ImmunoAngiogenic Niche for Homologous

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Journal of enzyme inhibition and medicinal chemistry

Application:

IF:

5.75

Species:

Homo sapiens

PMID:

38059334

Title:

Searching for novel MDM2/MDMX dual inhibitors through a drug repurposing approach

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Virulence

Application:

IF:

5.42

Species:

Sus scrofa

PMID:

38018865

Title:

LRRC8A promotes Glaesserella parasuis cytolethal distending toxin-induced p53-dependent apoptosis in NPTr cells

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Frontiers in pharmacology

Application:

IHC

IF:

5.98

Species:

Homo sapiens

PMID:

38239193

Title:

Klotho-derived peptide KP1 ameliorates SARS-CoV-2-associated acute kidney injury - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Cancer cell international

Application:

IHC

IF:

6.42

Species:

Mus musculus

PMID:

38273320

Title:

CircRAD23B promotes proliferation and carboplatin resistance in ovarian cancer cell lines and organoids - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Haemophilia : the official journal of the World Federation of Hemophilia

Application:

IF:

4.26

Species:

Homo sapiens

PMID:

38058260

Title:

Iron overload causes macrophages to produce a proinflammatory phenotype in the synovium of hemophiliac arthritis via the acetylp53 pathway

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Journal of hazardous materials

Application:

IF:

13.6

Species:

Mus musculus

PMID:

38401214

Title:

Low-Dose Deoxynivalenol Exposure Inhibits Hepatic Mitophagy and Hesperidin Reverses This Phenomenon by Activating SIRT1

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

The Science of the total environment

Application:

IF:

9.8

Species:

Homo sapiens

PMID:

38061639

Title:

Inhalation of ammonia promotes apoptosis and induces autophagy in hepatocytes via Bax/BCl-2 and m-TOR/ATG5/LC-3bII axes

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Asian Pacific journal of cancer prevention : APJCP

Application:

IHC

IF:

Species:

Homo sapiens

PMID:

35485694

Title:

Brazilin Isolated from Caesalpina Sappan Wood Induces Intrinsic Apoptosis on A549 Cancer Cell Line by Increasing p53, caspase-9, and caspase-3

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Clinical and experimental pharmacology & physiology

Application:

WB, IF

IF:

2.96

Species:

Homo sapiens

PMID:

36222180

Title:

Extrinsic apoptosis and senescence involve in growth kinetics of seminoma to cisplatin

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Biochemical pharmacology

Application:

WB, IHC, IF

IF:

6.1

Species:

Rattus norvegicus

PMID:

37863322

Title:

20-Deoxyingenol alleviates intervertebral disc degeneration by activating TFEB in nucleus pulposus cells

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Toxicology Letters

Application:

WB, IHC

IF:

4.271

Species:

Rattus norvegicus

PMID:

30172000

Title:

Excessive apoptosis and disordered autophagy flux contribute to the neurotoxicity induced by high iodine in Sprague-Dawley rat.

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Molecular cancer

Application:

IHC, WB

IF:

37.3

Species:

Homo sapiens

PMID:

38515149

Title:

CircHAS2 activates CCNE2 to promote cell proliferation and sensitizes the response of colorectal cancer to anlotinib

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Bioorganic chemistry

Application:

IF:

5.1

Species:

Homo sapiens

PMID:

38493636

Title:

Efficient assembly and anti-tumor evaluation of novel polycyclic [1, 2-a]-fused indoles

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

European journal of medicinal chemistry

Application:

IP, WB

IF:

6.7

Species:

Homo sapiens

PMID:

38417218

Title:

Identification of a ferritinophagy inducer via sinomenine modification for the treatment of colorectal cancer

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Aging and disease

Application:

IF, WB

IF:

7.4

Species:

Mus musculus

PMID:

38447216

Title:

An Antibody-directed and Immune Response Modifier-augmented Photothermal Therapy Strategy Relieves Aging via Rapid Immune Clearance of Senescent Cells - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Veterinary research forum : an international quarterly journal

Application:

IHC

IF:

Species:

Canis familiaris

PMID:

38465317

Title:

Cell proliferation and apoptosis in canine oral papillomatosis - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Molecules (Basel, Switzerland)

Application:

IF:

4.6

Species:

Homo sapiens

PMID:

38930897

Title:

Fucoxanthin Induces Ferroptosis in Cancer Cells via Downregulation of the Nrf2/HO-1/GPX4 Pathway - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Cellular signalling

Application:

IF:

4.8

Species:

Homo sapiens

PMID:

38810862

Title:

KLF11 promotes the proliferation of breast cancer cells by inhibiting p53-MDM2 signaling

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Scientific reports

Application:

IHC

IF:

4.6

Species:

Rattus norvegicus

PMID:

38429394

Title:

Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-B p65/GPX4 signaling pathway - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Inflammation

Application:

IF:

5.1

Species:

Homo sapiens

PMID:

38913144

Title:

Non-Canonical STING-PERK Pathway Modulation of Cellular Senescence and Therapeutic Response in Sepsis-Associated Acute Kidney Injury

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

International immunopharmacology

Application:

IF:

5.6

Species:

Mus musculus

PMID:

38810310

Title:

Direct targeting of S100A9 with Icariin counteracted acetaminopheninduced hepatotoxicity

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Application:

IF:

7.5

Species:

Homo sapiens,Mus musculus

PMID:

38917760

Title:

Inhibition of DNMTs increases neoantigen-reactive T-cell toxicity against microsatellite-stable colorectal cancer in combination with radiotherapy

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Endocrinology

Application:

IF:

4.8

Species:

Homo sapiens

PMID:

38679470

Title:

BMP4 in human endometrial stromal cells can affect decidualization by regulating FOXO1 expression

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Cell death & disease

Application:

IF:

Species:

Mus musculus

PMID:

39160159

Title:

The involvement of the Stat1/Nrf2 pathway in exacerbating Crizotinib-induced liver injury: implications for ferroptosis - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Journal of Cancer

Application:

IF:

3.9

Species:

Mus musculus

PMID:

29158805

Title:

Histone Methyltransferase SETDB1 Promotes the Progression of Colorectal Cancer by Inhibiting the Expression of TP53.

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Am J Transl Res

Application:

IF:

2.2

Species:

Homo sapiens

PMID:

33594313

Title:

MiR-543/Numb promotes proliferation, metastasis, and stem-like cell traits of prostate cancer cells

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

The Journal of surgical research

Application:

IF:

2.2

Species:

Rattus norvegicus

PMID:

30502252

Title:

SIRT3 inactivation promotes acute kidney injury through elevated acetylation of SOD2 and p53

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

iScience

Application:

IF:

5.8

Species:

Mus musculus

PMID:

39290834

Title:

The role of mitofusin 2 in regulating endothelial cell senescence: Implications for vascular aging - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Cellular signalling

Application:

IF:

4.8

Species:

Homo sapiens

PMID:

38729325

Title:

SMC2 knockdown inhibits malignant progression of lung adenocarcinoma by upregulating BTG2 expression

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Heliyon

Application:

IF:

Species:

Homo sapiens

PMID:

39258188

Title:

Pharmaceutical inhibition of BCL6 ameliorates resistance to imatinib in chronic myeloid leukemia - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Nature communications

Application:

IF:

16.6

Species:

Homo sapiens

PMID:

30679505

Title:

Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie.

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Free Radic Biol Med

Application:

IF:

7.4

Species:

Rattus norvegicus

PMID:

33588051

Title:

Lithium chloride represses abdominal aortic aneurysm via regulating GSK3/SIRT1/NF-B signaling pathway

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Toxicology

Application:

IF:

4.5

Species:

Rattus norvegicus

PMID:

37059347

Title:

The novel polyfluoroalkyl benzenesulfonate OBS exposure induces cell cycle arrest and senescence of rat pituitary cell GH3 via the p53/p21/RB pathway

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Journal of biomedical science

Application:

IF:

Species:

Mus musculus

PMID:

39237902

Title:

Tudor-SN exacerbates pathological vascular remodeling by promoting the polyubiquitination of PTEN via NEDD4-1 - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Cellular and molecular life sciences : CMLS

Application:

IF:

6.2

Species:

Mus musculus

PMID:

39460804

Title:

The pluripotent-to-totipotent state transition in mESCs activates the intrinsic apoptotic pathway through DUX-induced DNA replication stress - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Free radical biology & medicine

Application:

IF:

7.1

Species:

Rattus norvegicus

PMID:

38286317

Title:

Targeting ERS-mitophagy in hippocampal neurons to explore the improvement of memory by tea polyphenols in aged type 2 diabetic rats

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Journal of cellular and molecular medicine

Application:

IF:

5.3

Species:

Rattus norvegicus

PMID:

39428562

Title:

The Nterminal fragment of histone deacetylase 4 (1669aa) promotes chondrocyte apoptosis via the p53dependent endoplasmic reticulum stress pathway - PMC

References for [KO Validated] p53 Rabbit pAb (A0263)

Product:

[KO Validated] p53 Rabbit pAb

Journal:

Phytomedicine : international journal of phytotherapy and phytopharmacology

Application:

IF:

6.7

Species:

Homo sapiens

PMID:

38569296